Results 61 to 70 of about 750,316 (378)

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]

, 2009
Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

4-[(4-Chlorophenyl)carbamoyl]butanoic Acid

Molbank, 2021
The X-ray crystal structure determination of the glutaric acid-amide derivative, 4-ClC6H4N(H)C(=O)(CH2)3C(=O)OH (1), is described. The backbone of the molecule adopts an extended, all-trans configuration but the terminal carboxylic acid and phenyl ...
Bibi Hanifa, Muhammad Sirajuddin, Ahmed Bari, See Mun Lee, Kong Mun Lo, Edward R. T. Tiekink   +5 more
doaj   +1 more source

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Structure, Conformation and Contact Analyses of Six Aromatic Diamide Diesters

Crystals, 2023
Six meta-substituted isophthalamide diesters (DxE) and pyridinedicarboxamides (PxE) are reported with spectroscopic and crystal structure analyses (D = meta-C6H4; P = meta-pyridine; xE = 2-/3-/4-ethyl ester substitution). Comparisons are made between the
Islam Ali Osman, Vickie McKee, Christian Jelsch, John F. Gallagher   +3 more
doaj   +1 more source

Quantum and classical vibrational relaxation dynamics of N-methylacetamide on ab initio potential energy surfaces

, 2008
Employing extensive quantum-chemical calculations at the DFT/B3LYP and MP2 level, a quartic force field of isolated N-methylacetamide is constructed.
Ankerhold, Ataka, Barone, Barth, Bounouar, Bowman, Bowman, Bowman, Brooks, Carter, Carter, Cremeens, DeFlores, Dijkstra, Egorov, Egorov, Frisch, Fujisaki, Fujisaki, Fujisaki, Fujisaki, Gatti, Giese, Gorbunov, Gregurick, Gruebele, Gruebele, Guo, Ham, Hamm, Hayashi, Ka, Kaledin, Keyes, Kobus, Kongsted, Krimm, Krishnan, Kühn, Lawrence, Leitner, Leitner, MacKerell, Moritsugu, Moritsugu, Müller, Nguyen, Ohmine, Ohmine, Pouthier, Rauhut, Schinke, Schmidt, Stock, Stratt, Taketsugu, Toffoli, Torii, Torii, van der Spoel, Voth, Yagi, Yagi, Yagi, Yagi, Yoshida, Zanni   +66 more
core   +1 more source

Insights into the mechanism for gold catalysis: behaviour of gold(i) amide complexes in solution [PDF]

, 2013
We report the synthesis and activity of new mononuclear and dinuclear gold amide complexes . The dinuclear complexes and were characterised by single crystal X-ray analysis.
Alker, Bayler, Benitez, Berners-Price, Brandys, Brown, Chao, Delfs, Eddy M. E. Viseux, Forward, Frelek, Gao, Hashmi, Healy, Huo, Iain J. Day, Johnson Jr., Kanai, Kennedy-Smith, Khin, Macchioni, Mariusz Bobin, Mézailles, Nguyen, Nilsson, Noey, Saito, Schmidbaur, Schmidbaur, Stephen M. Roe, Teles, Toullec, Uson, Vicente, Vicente   +34 more
core   +1 more source

Amide Bond Activation of Biological Molecules

Molecules, 2018
Amide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and
S. Mahesh, kuei-chien Tang, M. Raj
semanticscholar   +1 more source