Results 41 to 50 of about 133,532 (244)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Amide Moieties Modulate the Antimicrobial Activities of Conjugated Oligoelectrolytes against Gram‐negative Bacteria

ChemistryOpen, 2022
Cationic conjugated oligoelectrolytes (COEs) are a class of compounds that can be tailored to achieve relevant in vitro antimicrobial properties with relatively low cytotoxicity against mammalian cells.
Jakkarin Limwongyut, Dr. Alex S. Moreland, Dr. Chenyao Nie, Prof. Javier Read de Alaniz, Prof. Guillermo C. Bazan   +4 more
doaj   +1 more source

Synthesis of indoles via alkylidenation of acyl hydrazides [PDF]

, 2009
Indoles have been synthesised via alkylidenation of acyl phenylhydrazides using phosphoranes and the Petasis reagent, followed by in situ thermal rearrangement of the product enehydrazines.
Commeureuc, A.G.J., EPSRC (Funder), Hisler, K., Murphy, J.A., WestCHEM (Funder), Zhou, S.Z.   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ammonothermal Synthesis and Crystal Structures of Diamminetriamidodizinc Chloride [Zn2(NH3)2(NH2)3]Cl and Diamminemonoamidozinc Bromide [Zn(NH3)2(NH2)]Br

Inorganics, 2016
The treatment of excess zinc in the presence of ammonium chloride under ammonothermal conditions of 873 K and 97 MPa leads to diamminetriamidodizinc chloride [Zn2(NH3)2(NH2)3]Cl with a two-dimensionally μ-amido-interconnected substructure.
Theresia M. M. Richter, Sabine Strobel, Nicolas S. A. Alt, Eberhard Schlücker, Rainer Niewa   +4 more
doaj   +1 more source

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]

, 2015
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib, Bode H. B., Degnan B. M., Dohi T., Dohi T., Fujita M., Fujita M., Guilbault A.-A., Guilbault A.-A., Hamnett D. J., Kong A., Mizar P., Moon N. G., Murai T., Ngatimin M., Parra A., Richardson R. D., Rodríguez A., Rodríguez A., Shimogaki M., Somaia Kamouka, Suzuki S., Uyanik M., Uyanik M., Wesley J. Moran, Wu H., Yan J., Zhdankin V. V., Zheng Z. S., Zhong W., Zhou Z.-S.   +30 more
core   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds

Communications Chemistry
Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification.
Hongjian Qin, Zijian Han, Emmanuel Mintah Bonku, Haiguo Sun, Abdullajon Odilov, Fuqiang Zhu, Safomuddin Abduahadi, Weiliang Zhu, Jingshan Shen, Haji A. Aisa   +9 more
doaj   +1 more source

Synthesis and anion recognition properties of shape-persistent binaphthyl-containing chiral macrocyclic amides

Beilstein Journal of Organic Chemistry, 2012
We report on the synthesis and characterization of novel shape-persistent, optically active arylamide macrocycles, which can be obtained using a one-pot methodology.
Marco Caricato, Nerea Jordana Leza, Claudia Gargiulli, Giuseppe Gattuso, Daniele Dondi, Dario Pasini   +5 more
doaj   +1 more source

Impact of Sustainable Binders Based on Lignin and Collagen on the Volume Stability and Mechanical Properties of MgO‐C Refractories with MgO‐C Recyclates

Advanced Engineering Materials, EarlyView.
Collagen hydrolysate is evaluated as a sustainable binder for MgO‐C refractories. Its thermally induced cross‐linking and gas release lead to expansion and cracking in large bricks, but tailored batches with lignin, recyclates, or fine graphite improve the gas release while thermal treatment and stability.
Till M. J. Stadtmüller, Florian Kerber, Kirsten Moritz, Steffen Dudczig, Konstantin Kraushaar, Thomas Schemmel, Jana Hubálková, Patrick Gehre, Christos G. Aneziris   +8 more
wiley   +1 more source