Results 51 to 60 of about 173,620 (335)

Amide Activation by Tf2O: Reduction of Amides to Amines by NaBH4 under Mild Conditions [PDF]

, 2010
An expeditious and practical method for the reduction of amides to amines is reported. The method is consisted of activation of amides with Tf2O followed by reduction with sodium borohydride in THF at room temperature.
Huang, Pei-Qiang, Xiang, Shao-Hua, Xu, Jian, Yuan, Hong-Qiu, 黄培强   +4 more
core   +1 more source

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source

Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds

Communications Chemistry
Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification.
Hongjian Qin, Zijian Han, Emmanuel Mintah Bonku, Haiguo Sun, Abdullajon Odilov, Fuqiang Zhu, Safomuddin Abduahadi, Weiliang Zhu, Jingshan Shen, Haji A. Aisa   +9 more
doaj   +1 more source

Chemistry of Bridged Lactams: Recent Developments

Molecules, 2019
Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765).
Roman Szostak, Michal Szostak
doaj   +1 more source

Esters and amides of 3-R-2,8-dioxo-7,8-dihydro2H-pyrrolo[1,2-a][1,2,4]­triazino[2,3-c]quinazolin-5a(6H)-carboxylic(-propanoic) acids: synthesis and biological activity

Журнал органічної та фармацевтичної хімії, 2020
It is known that carboxyl groups bonded to aryl or hetaryl moieties play a role of the “pharmacophore” fragment in most NSAID molecules. It should be mentioned that the carboxyl group may cause the appearance of toxic effects and is characterized by ...
Viktor V. Stavytskyi, Inna S. Nosulenko, Kostiantyn I. Kandybey, Oleksii Yu. Voskoboinik, Serhii I. Kovalenko   +4 more
doaj   +1 more source

The Mode of Protonation of Amides [PDF]

, 1958
The relative basicities of oxygen versus nitrogen in amides is a problem which has not been satisfactorily resolved. However, it might be anticipated from considerations of resonance and structural parameters that in strongly acidic solutions the proton ...
Fraenkel, Gideon, Niemann, Carl
core   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile: A key intermediate for dipeptidyl peptidase IV inhibitors

Beilstein Journal of Organic Chemistry, 2008
An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into ...
Santosh K. Singh, Narendra Manne, Manojit Pal   +2 more
doaj   +1 more source

Synthesis of amides and esters containing furan rings under microwave-assisted conditions

Open Chemistry, 2021
In this work, we present a novel method for the synthesis of ester and amide derivatives containing furan rings (furfural derivatives) under mild synthetic conditions supported by microwave radiation.
Janczewski Łukasz, Zieliński Dariusz, Kolesińska Beata   +2 more
doaj   +1 more source

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides [PDF]

, 2015
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route.
Ali Alhalib, Bode H. B., Degnan B. M., Dohi T., Dohi T., Fujita M., Fujita M., Guilbault A.-A., Guilbault A.-A., Hamnett D. J., Kong A., Mizar P., Moon N. G., Murai T., Ngatimin M., Parra A., Richardson R. D., Rodríguez A., Rodríguez A., Shimogaki M., Somaia Kamouka, Suzuki S., Uyanik M., Uyanik M., Wesley J. Moran, Wu H., Yan J., Zhdankin V. V., Zheng Z. S., Zhong W., Zhou Z.-S.   +30 more
core   +1 more source