Results 51 to 60 of about 3,968 (220)

Copper-catalyzed aerobic [3+2] : annulation of N-alkenyl amidines

, 2012
A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines.
Zhu, Xu, Wang, Yi-Feng, Chiba, Shunsuke
core   +1 more source

Regiochemistry of cyclocondensation reactions in the synthesis of polyazaheterocycles

Beilstein Journal of Organic Chemistry, 2017
The syntheses of several polyazaheterocycles are demonstrated. The cyclocondensation reactions between β-enaminodiketones [CCl3C(O)C(=CNMe2)C(O)-CO2Et] and aromatic amidines resulted in glyoxalate-substituted pyrido[1,2-a]pyrimidinone, thiazolo[3,2-a ...
Patrick T. Campos, Leticia V. Rodrigues, Andrei L. Belladona, Caroline R. Bender, Juliana S. Bitencurt, Fernanda A. Rosa, Davi F. Back, Helio G. Bonacorso, Nilo Zanatta, Clarissa P. Frizzo, Marcos A. P. Martins   +10 more
doaj   +1 more source

(E)-N-[Cyclopentyl(morpholin-4-yl)methylidene]-4-fluorobenzenesulfonamide

IUCrData, 2016
The title compound, C16H21FN2O3S, was obtained from the reaction between sulfonyl azide, cyclohexanone and morpholine. The bond lengths at the amidine N—C—N grouping are similar [1.326 (3) and 1.338 (3) Å], indicating significant conjugation.
Ilya Efimov, Pavel Slepukhin, Nikolai Beliaev, Vasiliy Bakulev   +3 more
doaj   +1 more source

Katalysatoraktivierung als Schlüsselfaktor in Kreuzkupplungen: Raumtemperatur‐Kupplungen schwacher Nukleophile ermöglicht durch [Pd(1‐MeNAP)TFA]2 Präkatalysatoren

Angewandte Chemie, EarlyView.
Bei vielen Pd‐katalysierten Kreuzkupplungen hat sich gezeigt, dass die Katalysatorleistung durch dessen Aktivierung begrenzt wird. Methylnaphthyl (MeNAP)‐Palladiumtrifluoracetat‐Dimere werden als leicht zu lagernde und handhabende Präkatalysatoren vorgestellt, die sich unter Reaktionsbedingungen schnell aktivieren, selbst wenn nur schwach ...
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Activation of carbon dioxide by bicyclic amidines

, 2004
Activation of the carbon dioxide molecule was achieved using bicyclic amidines (DBU, PMDBD, and DBN). The solution reaction of CO2 with amidines yielded the corresponding zwitterionic complexes through the formation of a N-CO2 bond.
RODRIGUES-FILHO, Ubirajara P., FRANCO, Douglas W., PÉREZ, Eduardo R., GAMBARDELLA, Maria T. P., LAUNAY, Jean-Claude, SANTOS, Regina H. A., DE MACEDO, Luiz G. M.   +6 more
core   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, EarlyView.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Ligand-Free Copper-Catalyzed Arylation of Amidines

, 2016
Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free conditions.
Corey Garvin (2226562), Jon C. Antilla (1334853), Michelle Cortes-Salva (2226559)   +2 more
core   +1 more source

1,3-Dipolar Cycloaddition (Part II): Three-Component Cu(I) Catalysed Click Reactions [PDF]

Kemija u Industriji, 2015
The Cu(I) catalysed reaction of sulfonyl or phosphoryl azide and terminal alkyne obtains a ketenimine intermediate that reacts with nucleophiles like water, alcohols, amines, imines, pyrroles or indoles producing corresponding amides, imidates, amidines ...
Krstulović L. , Saftić D. , Matić J. , Bajić M. , Žinić B.   +4 more
doaj   +1 more source

Unlocking Catalyst Activation as a Critical Bottleneck in Cross‐Coupling Reactions: Room‐Temperature Couplings of Weak Nucleophiles Enabled by [Pd(1‐MeNAP)TFA]2 Precatalysts

Angewandte Chemie International Edition, EarlyView.
In many Pd‐catalyzed cross‐couplings, catalyst performance has been found to be limited by catalyst activation. Methylnaphthyl (MeNAP) palladium trifluoroacetate dimers are presented as easy‐to‐store and easy‐to‐handle precursors, which rapidly activate under reaction conditions, even when only weakly coordinating, non‐reducing nucleophiles are present.
Sourav Manna, Henric F. Janning, Nikolaos V. Tzouras, Jane Anto Simplica Sagayaraj, Fadil Faizal Mannighayil, Angelino Doppiu, Lukas J. Gooßen   +6 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source