Results 31 to 40 of about 3,968 (220)

Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses

Molecules, 2021
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections.
Anita Toscani, Rossana Denaro, Sergio Fernando Castillo Pacheco, Matteo Biolatti, Silvia Anselmi, Valentina Dell’Oste, Daniele Castagnolo   +6 more
doaj   +1 more source

Susceptibility of Amblyomma sculptum, Vector of Rickettsia rickettsii, Ticks from a National Park and an Experimental Farm to Different Synthetic Acaricides

Pathogens, 2023
Amblyomma sculptum is a relevant tick species from a One Health perspective, playing an important role as a vector of Rickettsia rickettsii, the main agent of spotted fever rickettsiosis in Brazil. In this study, we evaluated the susceptibility of two A.
Ennya Rafaella Neves Cardoso, Stephani Félix Carvalho, Sarah Alves Dias, Rayane Almeida Santos, Mariana Avelar Tavares, Lucianne Cardoso Neves, Warley Vieira de Freitas Paula, Gracielle Teles Pádua, Nicolas Jalowitzki de Lima, Raquel Loren dos Reis Paludo, Isabela Santos Silva, Raphaela Bueno Mendes Bittencourt, Gabriel Cândido dos Santos, Flavia Giovana de Jesus Nascimento, Luiza Gabriella Ferreira de Paula, Filipe Dantas-Torres, Caio Marcio De Oliveira Monteiro, Felipe da Silva Krawczak   +17 more
doaj   +1 more source

Amidine Dications as Superelectrophiles

Journal of the American Chemical Society, 2009
2-Dimethylalkylammonium pyridinium and 2-dimethylalkylammonium pyrimidinium ditriflate salts are very powerful methylating agents toward phosphorus (triphenylphosphine) and nitrogen (triethylamine) nucleophiles. In competition experiments with triethylamine as nucleophile, these N-methyl disalts are more reactive methylating agents than dimethyl ...
Corr, Michael J, Roydhouse, Mark D, Gibson, Kirsty F, Zhou, Sheng-Ze, Kennedy, Alan R, Murphy, John A   +5 more
openaire   +4 more sources

Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives

Molecules, 2021
Newly designed and synthesized cyano, amidino and acrylonitrile 2,5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor and antimicrobial activity.
Livio Racané, Ivo Zlatar, Nataša Perin, Maja Cindrić, Vedrana Radovanović, Mihailo Banjanac, Suresh Shanmugam, Marijana Radić Stojković, Karmen Brajša, Marijana Hranjec   +9 more
doaj   +1 more source

Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines

Molecules, 2022
A series of cyano- and amidino-substituted imidazo[4,5-b]pyridines were synthesized using standard methods of organic synthesis, and their biological activity was evaluated.
Ida Boček Pavlinac, Katarina Zlatić, Leentje Persoons, Dirk Daelemans, Mihajlo Banjanac, Vedrana Radovanović, Kristina Butković, Marijeta Kralj, Marijana Hranjec   +8 more
doaj   +1 more source

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro.
Livio Racané, Maja Cindrić, Ivo Zlatar, Tatjana Kezele, Astrid Milić, Karmen Brajša, Marijana Hranjec   +6 more
doaj   +1 more source

Influence of Steric Effect on the Pseudo-Multicomponent Synthesis of N-Aroylmethyl-4-Arylimidazoles

Molecules, 2022
A pseudo-three-component synthesis of N-aroylmethylimidazoles 3 with three new C–N bonds formed regioselectively under microwave conditions was developed.
Nerith Rocio Elejalde-Cadena, Mayra García-Olave, David Figueroa, Pietro Vidossich, Gian Pietro Miscione, Jaime Portilla   +5 more
doaj   +1 more source

Three-Component Reaction of Tautomeric Amidines with 3-Ferrocenylmethylidene-2,4-pentanedione. Formation of Polymeric Coordination Complexes of Potassium Ferrocenyl-(hexahydro)pyrimidoxides

Molecules, 2013
Acetamidine hydrochloride and p-aminobenzamidine dihydrochloride interact with 3-ferrocenylmethylidene-2,4-pentanedione at 80–82 °C in the presence of K2CO3 in the water–alcohol medium in two tautomeric forms (the amidoimine and enediamine ones) with ...
Elena I. Klimova, Marcos Flores-Alamo, Tatiana Klimova, Sandra Cortez Maya, Irina P. Beletskaya   +4 more
doaj   +1 more source

Synthesis of Amidines and Its Application to Pyrimidouracil Synthesis

, 2020
An efficient and sustainable copper-catalyzed protocol has been developed for the preparation of amidines via nucleophilic addition of amines into nitriles.
Pradip Debnath
core   +1 more source

Acaricide resistance of Rhipicephalus decoloratus ticks collected from communal grazing cattle in South Africa

Journal of Advanced Veterinary and Animal Research, 2022
Objective: This study aimed to determine acaricide resistance in Rhipicephalus decoloratus ticks collected from grazing cattle between November 2018 and May 2019 in Elundini, Senqu, and Walter Sisulu Local Municipalities in the northeastern region of the
Mandla Yawa, Nkululeko Nyangiwe, Ishmael Festus Jaja, Munyaradzi Christopher Marufu, Charles T. Kadzere   +4 more
doaj   +1 more source