Results 71 to 80 of about 7,050 (214)
Cancer Nexus, EarlyView.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Журнал органічної та фармацевтичної хіміїThe literature review discusses and systematizes synthetic approaches to medium-sized cycles and macrocycles based on ring expansion reactions of bi- or polycyclic systems via C-N bond cleavage. Ring expansion reactions of bicyclic ammonium salts proceed
Viacheslav Lysenko +2 more
doaj +1 more source
, 2014 Citation: 'amidines' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00267 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Cyanoacetamidobetaine—A Zwitterionic Nitrile Derivative
ChemistryOpen, EarlyView.The reaction of sodium dicyanamide with betainium chloride in aqueous solution affords N‐cyano‐2‐(trimethylammonio)acetaminide (cyanoacetamidobetaine). Single crystal X‐ray diffraction reveals a monoclinic structure comprising a trimethylammonium head group connected to a cyanoacetaminide unit via a methylene bridge.
Pan Duan +5 more
wiley +1 more source
Pest Management Science, EarlyView.XXXX Abstract BACKGROUND Spodoptera frugiperda, commonly known as the fall armyworm, is a highly economically significant pest that affects various crops, resulting in substantial losses in productivity. Managing this pest primarily relies on chemical insecticides; however, the repeated development of resistance to these chemicals has rendered them ...
Daniel Guimarães Silva Paulo +9 more
wiley +1 more source
CHIMIA, 1976 A new synthesis of 2,4-bis(dialkylamino)-pyridines and quinolines is reported. Starting from primary aryl amines or aliphatic imines a mechanism via ynamine-amidines is followed if the cyanine Ia is used as reagent. When the cyanine is substituted, (I.R.
H.G. Viehe, G.J. de Voghel, F. Smets
doaj +1 more source
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Perfluoroether triazine elastomers [PDF]
The synthesis of high performance elastomers with the high thermal stability and chemical, inertness of perfluoroalkylene triazine and a low glass transition temperature is discussed.
Korus, R. A.
core +1 more source
High performance channel injection sealant invention abstract [PDF]
High performance channel sealant is based on NASA patented cyano and diamidoximine-terminated perfluoroalkylene ether prepolymers that are thermally condensed and cross linked.
Basiulis, D. I. +2 more
core +1 more source
Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines [PDF]
, 2018 Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation of biochemical roles, in particular that of vitamin B1.
Hughes, David L. +3 more
core +3 more sources