Molecular Metabolism, 2021 Objective: Metabolic deregulation is a key hallmark of cancer cells and has been shown to drive cancer growth and metastasis. However, not all metabolic drivers of melanoma are known.
Parmanand Malvi +4 more
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Allantoate Amidohydrolase OsAAH is Essential for Preharvest Sprouting Resistance in Rice [PDF]
RicePreharvest sprouting (PHS) is an undesirable trait that decreases yield and quality in rice production. Understanding the genes and regulatory mechanisms underlying PHS is of great significance for breeding PHS-resistant rice.
Ting Xie +10 more
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Aspergillus niger Ochratoxinase Is a Highly Specific, Metal-Dependent Amidohydrolase Suitable for OTA Biodetoxification in Food and Feed. [PDF]
J Agric Food ChemMicrobial enzymes can be used as processing aids or additives in food and feed industries. Enzymatic detoxification of ochratoxin A (OTA) is a promising method to reduce OTA content.
Sánchez-Arroyo A +4 more
europepmc +4 more sources
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily. [PDF]
Angew Chem Int Ed EnglComprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Drexler L +3 more
europepmc +4 more sources
Revisiting D‐Acylases for D‐Amino Acid Production [PDF]
Microbial BiotechnologyN‐Acyl‐D‐amino acid deacylases (EC 3.5.1.81, also known as D‐acylases) have been studied for decades for their utility in the kinetic resolution of N‐acetyl‐D,L‐amino acids (NAAs) due to a marked stereospecificity. In conjunction with an N‐succinyl‐amino
Sergio Martínez‐Rodríguez +1 more
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Bacterial amidohydrolases and modified 5-fluorocytidine compounds: Novel enzyme-prodrug pairs. [PDF]
PLoS ONE, 2023 Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells.
Viktorija Preitakaitė +6 more
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Safety evaluation of the food enzyme asparaginase from the non‐genetically modified Saccharomyces cerevisiae strain ARY‐2 [PDF]
EFSA JournalThe asparaginase (L‐asparagine amidohydrolase, EC 3.5.1.1) is produced by the non‐genetically modified Saccharomyces cerevisiae strain ARY‐2 by Renaissance BioScience Corporation.
EFSA Panel on Food Enzymes (FEZ) +16 more
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Safety evaluation of the food enzyme asparaginase from the non‐genetically modified Saccharomyces cerevisiae strain ARY‐1 [PDF]
EFSA JournalThe asparaginase (l‐asparagine amidohydrolase, EC 3.5.1.1) is produced by the non‐genetically modified Saccharomyces cerevisiae strain ARY‐1 by Renaissance BioScience Corporation.
EFSA Panel on Food Enzymes (FEZ) +17 more
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Biomolecules, 2023 The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction.
Daniela Cederfelt +5 more
doaj +1 more source
Identification of a metabolic-related gene signature predicting the overall survival for patients with stomach adenocarcinoma [PDF]
PeerJ, 2021 Background The reprogramming of energy metabolism and consistently altered metabolic genes are new features of cancer, and their prognostic roles remain to be further studied in stomach adenocarcinoma (STAD).
Yuan Nie, Linxiang Liu, Qi Liu, Xuan Zhu
doaj +2 more sources