Results 101 to 110 of about 10,073 (196)

The structure of the hexameric atrazine chlorohydrolase AtzA

, 2015
Atrazine chlorohydrolase (AtzA) was discovered and purified in the early 1990s from soil that had been exposed to the widely used herbicide atrazine. It was subsequently found that this enzyme catalyzes the first and necessary step in the breakdown of ...
Balotra, S., Lucent, D., Newman, J., Peat, T. S., Scott, C., Warden, A. C.   +5 more
core   +1 more source

Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress[S]

Journal of Lipid Research, 2019
Over 11 million people in the United States alone have some form of age-related macular degeneration (AMD). Oxidative stress, cell death, and the degeneration of retinal pigment epithelial (RPE) cells contribute to AMD pathology. Recent evidence suggests
Eriko Sugano, Genea Edwards, Saikat Saha, Lynda A. Wilmott, Richard C. Grambergs, Koushik Mondal, Hui Qi, Megan Stiles, Hiroshi Tomita, Nawajes Mandal   +9 more
doaj   +1 more source

The Acylamide Amidohydrolase of Candida utilis: Purification and Properties [PDF]

Journal of General Microbiology, 1969
SUMMARY: The amidohydrolase formed in the later stages of growth on glucose peptone medium by Candida utilis was purified 60-fold from cell-free extracts. The purified enzyme hydrolysed mono- and di-carboxylic acid amides, benzamide, nicotinamide, pyrazinamide and certain β-hydroxyl substituted fatty acid amides, was inactive on l-asparagine and l ...
openaire   +2 more sources

Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent

Memorias do Instituto Oswaldo Cruz
The region of Antioquia in northeastern Colombia has the highest number of reported leptospirosis cases in the country. It also shows high seroprevalence indexes in the general population and socio-environmental conditions favourable for the transmission
Ronald Guillermo Peláez Sanchez, Juan Álvaro Lopez, Martha María Pereira, Margarita Arboleda Naranjo, Piedad Agudelo-Flórez   +4 more
doaj   +1 more source

Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis

Acta Biochimica Polonica
This report describes a comprehensive approach to local random mutagenesis of the E. coli Ntn-amidohydrolase EcAIII, and supplements the results published earlier for the randomization series RDM1.
Joanna I. Loch, Anna Ściuk, Anna Ściuk, Marta Kilichowska, Marta Kilichowska, Izabela Pieróg, Izabela Pieróg, Weronika Łukaszczyk, Katarzyna Zimowska, Mariusz Jaskolski, Mariusz Jaskolski   +10 more
doaj   +1 more source

Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis

Journal of Advanced Research
Introduction: Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the ...
Gang Wang, Wenqing Wu, Nancy P. Keller, Xu Guo, Erfeng Li, Junning Ma, Fuguo Xing   +6 more
doaj   +1 more source

Structural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase from Pseudomonas aeruginosa PAO1

Bioinorganic Chemistry and Applications, 2018
Dihydropyrimidinase, a dimetalloenzyme containing a carboxylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase.
Jen-Hao Cheng, Chien-Chih Huang, Yen-Hua Huang, Cheng-Yang Huang   +3 more
doaj   +1 more source

ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability

Cell Death and Disease
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to metastasis and therapy resistance. Owing to its aggressive nature and limited availability of targeted therapies, TNBC is associated with higher mortality as compared to ...
Kiran Kumar Reddi, Suresh Chava, Siva Chander Chabattula, Yvonne J. K. Edwards, Kamaljeet Singh, Romi Gupta   +5 more
doaj   +1 more source

A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials

Advanced Science
Inspired by the scar‐free wound healing in infants, an anti‐scar strategy is proposed by accelerating wound healing using silicate bioactive materials.
Zhaowenbin Zhang, Chen Fan, Qing Xu, Feng Guo, Wenbo Li, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang, Jiang Chang   +10 more
doaj   +1 more source

Exploring the Effect and Molecular Docking Interaction of Carboxypeptidase and Amidohydrolase on Ochratoxin A and Zearalenone Degradation

BioResources
To keep consumers from the hazard of exposure to mycotoxins and meet the allowed limits, numerous physical and chemical approaches for eliminating Ochratoxin A (OTA) and Zearalenone (ZEN) have been studied.
Sulaiman A. Alsalamah, Mohammed Ibrahim Alghonaim, Abdu Ali Y. Moafa, Mukul Sharma   +3 more
doaj