Results 11 to 20 of about 10,587 (231)

Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases

Biomolecules, 2022
The widespread superfamily of the human activating signal cointegrator homology (ASCH) domain was identified almost 20 years ago; however, the amount of experimental data regarding the biological function of the domain is scarce.
Roberta Statkevičiūtė, Mikas Sadauskas, Juta Rainytė, Karolina Kavaliauskaitė, Rolandas Meškys   +4 more
doaj   +4 more sources

Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen [PDF]

British Journal of Pharmacology, 2001
The pharmacological properties of fatty acid amidohydrolase (FAAH) at different assay pH values were investigated using [3H]‐anandamide ([3H]‐AEA) as substrate in rat brain homogenates and in COS‐7 cells transfected with wild type and mutant FAAH. Rat brain hydrolysis of [3H]‐AEA showed pH dependency with an optimum around pH 8‐9.
Sandra Holt, Jonas Nilsson, Romelda Omeir, Gunnar Tiger, Christopher J. Fowler   +4 more
  +9 more sources

Investigating the Pathological Relevance of N-acylsphingosine Amidohydrolase 2 (ASAH2) and Related Proteins in Alzheimer's Disease. [PDF]

Cureus
Khabazeh A, Cho E, Ekuta V, Kumar J, Poursahdi N, Wong T, Wu P, Lian G, Libermann T, Sheen V.   +9 more
europepmc   +2 more sources

Crystal structure of N-carbamyl-d-amino acid amidohydrolase with a novel catalytic framework common to amidohydrolases [PDF]

Structure, 2000
N-carbamyl-D-amino acid amidohydrolase (DCase) catalyzes the hydrolysis of N-carbamyl-D-amino acids to the corresponding D-amino acids, which are useful intermediates in the preparation of beta-lactam antibiotics. To understand the catalytic mechanism of N-carbamyl-D-amino acid hydrolysis, the substrate specificity and thermostability of the enzyme, we
Takahisa Nakai, Tomokazu Hasegawa, Eiki Yamashita, Masaki Yamamoto, Takashi Kumasaka, Tatzuo Ueki, Hirokazu Nanba, Yasuhiro Ikenaka, Satomi Takahashi, Mamoru Sato, Tomitake Tsukihara   +10 more
openalex   +4 more sources

A Thermostable Bacterial Metallohydrolase that Degrades Organophosphate Plasticizers. [PDF]

Chembiochem
This bacterial enzyme, cyclase‐phosphotriesterase (C‐PTE) from Ruegeria pomeroyi DSS‐3, shows significant potential for breaking down organophosphate pollutants. Beyond its capability to hydrolyze specific plasticizers such as triphenyl phosphate and tris(2‐chloropropyl) phosphate, C‐PTE's crystal structure reveals a binuclear zinc active site, and it ...
Ji D, Frkic RL, Delyami J, Larsen JS, Spence MA, Jackson CJ.   +5 more
europepmc   +2 more sources

Discovery and In Vitro Reconstitution of Closoxazole Biosynthesis from Pyxidicoccus fallax. [PDF]

Chembiochem
The myxobacterium Pyxidicoccus fallax is found to be a producer of benzoxazole‐containing natural products named closoxazoles. In vitro studies with the biosynthetic enzymes reveal new insights into the reaction mechanism for closoxazole formation.
Lernoud L, Jakob R, Warnick L, Marx ML, Winand L.   +4 more
europepmc   +2 more sources

Impact of Nutrition on Sphingolipid-Regulated Physiology: A Review. [PDF]

Mol Nutr Food Res
Sphingolipids (SLs) play a role in multiple, if not all physiological processes. This review summarizes the current knowledge on SLs and their role in (patho‐) physiological processes with special regard to dietary and transgenerational effects. Image was created with BioRender.com.
Voß J, Hornemann T, Belgardt BF.
europepmc   +2 more sources

Identification of a metabolic-related gene signature predicting the overall survival for patients with stomach adenocarcinoma [PDF]

PeerJ, 2021
Background The reprogramming of energy metabolism and consistently altered metabolic genes are new features of cancer, and their prognostic roles remain to be further studied in stomach adenocarcinoma (STAD).
Yuan Nie, Linxiang Liu, Qi Liu, Xuan Zhu
doaj   +2 more sources

The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Biomolecules, 2023
The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction.
Daniela Cederfelt, Dilip Badgujar, Ayan Au Musse, Bernhard Lohkamp, U. Helena Danielson, Doreen Dobritzsch   +5 more
doaj   +1 more source

Regulation of N-acetylkanamycin amidohydrolase in the idiophase in kanamycin fermentation. [PDF]

Agricultural and Biological Chemistry, 1976
Formation of N-acetylkanamycin amidohydrolase (NAKA) in a strain of Streptomyces kanamyceticus proceeded in parallel with the increase of both kanamycin (KM) and N-acetylkanamycin (NAK) in the initial period. NAKA formation then suddenly began to decrease in NAK but KM continued to increase before reaching a maximum level.
Atsuyuki Satoh, Hiroshi Ogawa, Yukio Satomura   +2 more
openalex   +4 more sources