Results 11 to 20 of about 12,409 (229)

Isoenzyme N-Acyl-l-Amino Acid Amidohydrolase NA Increases Ochratoxin A Degradation Efficacy of Stenotrophomonas sp. CW117 by Enhancing Amidohydrolase ADH3 Stability

Microbiology Spectrum, 2022
Ochratoxin A (OTA) is a potent mycotoxin mainly produced by toxicogenic strains of Aspergillus spp. and seriously contaminates foods and feedstuffs. OTA detoxification strategies are significant to food safety.
Nan Chen, Qingru Fei, Han Luo, Zemin Fang, Yazhong Xiao, Zhengjun Du, Yu Zhou   +6 more
doaj   +2 more sources

N-Carbamoylputrescine Amidohydrolase of Bacteroides thetaiotaomicron, a Dominant Species of the Human Gut Microbiota

Biomedicines, 2023
Polyamines are bioactive amines that play a variety of roles, such as promoting cell proliferation and protein synthesis, and the intestinal lumen contains up to several mM polyamines derived from the gut microbiota.
Hiromi Shimokawa, Mikiyasu Sakanaka, Yuki Fujisawa, Hirokazu Ohta, Yuta Sugiyama, Shin Kurihara   +5 more
doaj   +2 more sources

Heterologous Expression and Characterization of A Novel Ochratoxin A Degrading Enzyme, N-acyl-L-amino Acid Amidohydrolase, from Alcaligenes faecalis

Toxins, 2019
Ochratoxin A (OTA) is a well-known, natural contaminant in foods and feeds because of its toxic effects, such as nephrotoxicity in various animals. Recent studies have revealed that Alcaligenes faecalis could generate enzymes to efficiently degrade OTA ...
Honghai Zhang, Yunpeng Zhang, Tie Yin, Jing Wang, Xiaolin Zhang   +4 more
doaj   +2 more sources

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron [PDF]

Applied and Environmental Microbiology, 2015
The amidohydrolase superfamily has remarkable functional diversity, with considerable structural and functional annotation of known sequences. In microbes, the recent evolution of several members of this family to catalyze the breakdown of environmental ...
Carr, Paul D., Fraser, Nicholas J., Hopkins, Davis H., Jackson, Colin J., Khurana, Jeevan L., Nojiri, H., Oakeshott, John G., Scott, Colin, Sugrue, Elena   +8 more
core   +2 more sources

Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis

Journal of Advanced Research
Introduction: Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic gene cluster (BGC) to produce the ...
Gang Wang, Wenqing Wu, Nancy P. Keller, Xu Guo, Erfeng Li, Junning Ma, Fuguo Xing   +6 more
doaj   +2 more sources

Immobilization of the Amidohydrolase MxcM and Its Application for Biocatalytic Flow Synthesis of Pseudochelin A [PDF]

Catalysts, 2023
The chemical synthesis of heterocycles typically requires elevated temperature and acid or base addition to form the desired product. Moreover, these reactions often involve hazardous reagents, which is why biocatalytic routes for heterocycle formation ...
Lea Winand, Stefanie Theisen, Stephan Lütz, Katrin Rosenthal, Markus Nett   +4 more
openalex   +2 more sources

YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives [PDF]

Scientific Reports, 2020
Human activating signal cointegrator homology (ASCH) domain-containing proteins are widespread and diverse but, at present, the vast majority of those proteins have no function assigned to them. This study demonstrates that the 103-amino acid Escherichia
Rūta Stanislauskienė, Audrius Laurynėnas, Rasa Rutkienė, Agota Aučynaitė, Daiva Tauraitė, Rita Meškienė, Nina Urbelienė, Algirdas Kaupinis, Mindaugas Valius, Laura Kalinienė, Rolandas Meškys   +10 more
openalex   +2 more sources

ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Streptococcus pneumoniae is one of the leading pathogens that cause a variety of mucosal and invasive infections. With the increased emergence of multidrug-resistant S.
Hang Yang, Yujing Gong, Huaidong Zhang, Irina V. Etobayeva, Paulina Miernikiewicz, Dehua Luo, Xiaohong Li, Xiaoxu Zhang, Krystyna Dąbrowska, Daniel Nelson, Jin He, Hongping Wei   +11 more
openalex   +2 more sources

Characterization of a novel amidohydrolase with promiscuous esterase activity from a soil metagenomic library and its application in degradation of amide herbicides. [PDF]

Environ Sci Pollut Res Int
Amide herbicides have been extensively used worldwide and have received substantial attention due to their adverse environmental effects. Here, a novel amidohydrolase gene was identified from a soil metagenomic library using diethyl terephthalate (DET ...
Sun S, Chen W, Peng K, Chen X, Chen J.
europepmc   +2 more sources

The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development. [PDF]

Immun Inflamm Dis
The interplay between ferroptosis and the tumor immune microenvironment significantly influences the outcome of cancer immunotherapy. Inducing ferroptosis in tumor cells and immunosuppressive cells, while preventing ferroptosis in effector immune cells, emerges as a promising strategy to enhance the efficacy of immunotherapy. This review highlights the
Zhan F, Hu Y, Jiang X, Fang Z.
europepmc   +2 more sources