Results 41 to 50 of about 31,652 (216)

Pharmacokinetics of intranasal amiloride in healthy volunteers

Clinical and Translational Science, 2023
Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid‐sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and ...
Venkata K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim   +10 more
doaj   +1 more source

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]

, 1993
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson, Assaf, Ballanyi, Beaudry, Bonanno, Cabantchik, Chester, Combs, de Hemptinne, Deuticke, Deuticke, Dubinsky, Edlund, Grinstein, Halestrap, Halestrap, Halestrap, Halestrap, Halestrap, Hansen, Imai, Johnson, Juel, Kraig, Krnjević, Kuhr, Marrannes, Mason, Mutch, Poole, Poole, Poole, Poole, Raley-Susman, Roos, Roth, Scheller, Schneider, Schneider, Smith, Spencer, Strupp, Trosper, Walsh, Walz, Walz   +45 more
core   +1 more source

Nephrotic Syndrome: Oedema Formation and Its Treatment With Diuretics

Frontiers in Physiology, 2019
Oedema is a defining element of the nephrotic syndrome. Its’ management varies considerably between clinicians, with no national or international clinical guidelines, and hence variable outcomes.
Sanjana Gupta, Sanjana Gupta, Ruth J. Pepper, Neil Ashman, Stephen B. Walsh   +4 more
doaj   +1 more source

Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways [PDF]

, 2017
Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD,
Alejandro Pacheco, Alejandro Vallejos, Cesar Echeverria, Erico Segovia, Felipe Simon, Felipe Simon, Maria E. Sanhueza, Miriam Alvo, Pablo Tapia, Ricardo Armisen, Ricardo Armisen, Rubén Torres, Rubén Torres, Sebastian Gatica   +13 more
core   +2 more sources

Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma

iScience
Summary: The kidney is a vital organ responsible for water and sodium metabolism, while the primary function of amiloride is to promote the excretion of water and sodium. We investigated amiloride enhanced the sunitinib sensitivity in RCC.
Yuanyuan Bai, Yiqing You, Daoxun Chen, Yongmei Chen, Zhenjie Yin, Shangfan Liao, Bingyong You, Dongming Lu, Yingming Sun, Lixian Wu, Yongyang Wu   +10 more
doaj   +1 more source

Regulation of nephron acidification by corticosteroids

Brazilian Journal of Medical and Biological Research, 1997
The present paper reviews work from our laboratories evaluating the importance of adrenal cortical hormones in acidification by proximal and cortical distal tubules.
G. Malnic, M. Ansaldo, C.P. Lantos, M.C. Damasco   +3 more
doaj   +1 more source

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Renal Failure, 2021
Background Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis.
Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang   +15 more
doaj   +1 more source

Myocardial fibrosis in stroke survivors [PDF]

, 2015
Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac death ...
Allgar, V., MacWalter, R., McSwiggan, S., Struthers, A. D., Sze, S., Wong, K., Wong, S.   +6 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion [PDF]

, 2018
Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected.
Graham, V., Kenward, H., Lucas, M., McColl, S., McNaughton, E., Sabir, S., Tainsh, P., Turkington, C., Watson, P.   +8 more
core   +1 more source