Results 251 to 260 of about 71,396 (331)
Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li +11 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin +10 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.Lys–Leu MRPs heat‐treated for 2 h exhibited high antioxidant activity in vitro. A treatment with Lys–Leu MRPs extends the lifespan and health span of C. elegans by regulating ROS levels through their inherent antioxidant activity and the IIS pathway.
Yaqi Jia +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 1, January 2026.This study compared milk fat globule membrane protein (MFGMP) with whey protein concentrate (WPC) and micellar casein concentrate (MCC). The results revealed MFGMP's superior structural stability and amino acid profile, identified its unique proteomic landscape through label‐free quantification, and demonstrated its enhanced in vitro digestibility ...
Jiaming Wang +6 more
wiley +1 more source
Studies on polyamines. II. Metabolism of Spermidine and spermine by Amine Oxidase in Beef Serum.
, 1963 Tsutomu Unemoto
openalex +2 more sources
Glucose‐Responsive Modified Poly(Propylene Imine) Dendrimer for Self‐Regulated Insulin Delivery
Macromolecular Materials and Engineering, Volume 311, Issue 1, January 2026.Poly(propylene imine) dendrimers functionalized with phenolboronic acid (PBA) are synthesized and modified to develop a glucose‐sensitive system with a pKa of ∼7.4. Also, the equilibrium binding constant (Keq‐tet) for PBA‐attached G4 dendrimer (HB‐CBA) was determined to be 79 m−1.
Amin Hosseini Sharifabad +2 more
wiley +1 more source
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
Laccases from lactic acid bacteria show cuprous oxidase activity and capture Cu(II) and Ag(I) ions
Protein Science, Volume 35, Issue 1, January 2026.Abstract Several laccases derived from lactic acid bacteria (LAB) display specific structural features, such as two methionine residues at the entrance of the T1Cu center, and an extended C‐terminal end enriched in methionine and histidine. To investigate their functional roles, we engineered mutant variants of the laccase Pp4816 from Pediococcus ...
Raquel Gascó +6 more
wiley +1 more source
Small, Volume 22, Issue 5, 22 January 2026.Nucleic acid‐ligand conjugates combine the distinct properties of macromolecular ligands with the versatility of DNA/RNA nanotechnology. In biomaterial and nanomedicine applications, highly purified products are paramount, requiring reliable synthesis and purification methods.
Nico Alleva +4 more
wiley +1 more source