Results 1 to 10 of about 25,005 (227)

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy. [PDF]

Int J Retina Vitreous, 2021
Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
Boyer DS, Rippmann JF, Ehrlich MS, Bakker RA, Chong V, Nguyen QD.   +5 more
europepmc   +4 more sources

Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3. [PDF]

Open Biol, 2020
Zinc-α2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia.
Romauch M.
europepmc   +3 more sources

A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis. [PDF]

Nat Commun, 2023
Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled, multicentre trial (ClinicalTrials.gov: NCT03166735) investigated ...
Newsome PN, Sanyal AJ, Neff G, Schattenberg JM, Ratziu V, Ertle J, Link J, Mackie A, Schoelch C, Lawitz E, BI 1467335 NASH Phase IIa trial team.   +10 more
europepmc   +4 more sources

The tree of life of copper-containing amine oxidases. [PDF]

Front Plant Sci
Copper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic
Zhang Z, Xiong T, Li K, Huang K, Wu S, Wu L.   +5 more
europepmc   +3 more sources

Human Copper-Containing Amine Oxidases in Drug Design and Development [PDF]

Molecules, 2020
Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3 ...
Serhii Vakal, Sirpa Jalkanen, Käthe M. Dahlström, Tiina A. Salminen   +3 more
doaj   +5 more sources

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors [PDF]

Medicines, 2019
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper ...
Christian Carpéné, Nathalie Boulet, Alice Chaplin, Josep Mercader   +3 more
doaj   +2 more sources

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue [PDF]

Medicines, 2020
Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase.
Wiem Haj Ahmed, Cécile Peiro, Jessica Fontaine, Barry J. Ryan, Gemma K. Kinsella, Jeff O’Sullivan, Jean-Louis Grolleau, Gary T.M. Henehan, Christian Carpéné   +8 more
doaj   +3 more sources

Copper-containing amine oxidases contribute to terminal polyamine oxidation in peroxisomes and apoplast of Arabidopsis thaliana [PDF]

, 2021
Polyamines (PAs) are oxidatively deaminated at their primary or secondary amino-groups by copper-containing amine oxidases (CuAOs) or FAD-dependent amine oxidases (PAOs), respectively.
Altabella Artigas, Teresa, Gallart, Marta, Planas Portell, Joan, Tiburcio, Antonio F.   +3 more
core   +3 more sources

Mutation of Arabidopsis copper-containing amine oxidase gene AtCuAOδ alters polyamines, reduces gibberellin content and affects development [PDF]

, 2020
Polyamines (PAs) are essential metabolites in plants performing multiple functions during growth and development. Copper-containing amine oxidases (CuAOs) catalyse the catabolism of PAs and in Arabidopsis thaliana are encoded by a gene family.
Al-Harbi, Basmah, Colombo, Davide, Cona, Alessandra, Cort, Alex P., Davoli, Daniela, de Graaf, Barend, Dimitrova, Simone, Ghuge, Sandip A., Hunt, Julie D., Mariotti, Lorenzo, Muller, Carsten T., Picciarelli, Piero, Rogers, Hilary J., Spadafora, Natasha D.   +13 more
core   +4 more sources

Amine oxidase, copper containing 3 exerts anti‑mesenchymal transformation and enhances CD4⁺ T‑cell recruitment to prolong survival in lung cancer. [PDF]

Oncol Rep, 2021
Chang CY, Wu KL, Chang YY, Tsai PH, Hung JY, Chang WA, Jian SF, Huang YC, Chong IW, Tsai YM, Hsu YL.   +10 more
europepmc   +3 more sources