Results 31 to 40 of about 7,123 (216)
X-ray structural study of topaquinone biogenesis of copper containing amine oxidase
Seibutsu Butsuri, 2000 H. Yamaguchi +5 more
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Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases
Journal of Medicinal Chemistry, 2005 The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0 x 10(-8) corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a,b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied.
Vincenzo Bertini +9 more
openalex +5 more sources
CsCuAOs and CsAMADH1 Are Required for Putrescine-Derived γ-Aminobutyric Acid Accumulation in Tea
Foods, 2022 Polyamines are a potential source of γ-aminobutyric acid (GABA) in plants under abiotic stress. However, studies on GABA enrichment in tea mostly focus on the GABA shunt, while the correlation between polyamine degradation and GABA formation in tea is ...
Kexin Zhang +10 more
doaj +1 more source
Cell Death and Disease, 2022 Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer.
Yinghui Ding +10 more
doaj +1 more source
Biomedicines, 2021 SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth +17 more
doaj +1 more source
Laccases from lactic acid bacteria show cuprous oxidase activity and capture Cu(II) and Ag(I) ions. [PDF]
Protein SciAbstract Several laccases derived from lactic acid bacteria (LAB) display specific structural features, such as two methionine residues at the entrance of the T1Cu center, and an extended C‐terminal end enriched in methionine and histidine. To investigate their functional roles, we engineered mutant variants of the laccase Pp4816 from Pediococcus ...
Gascó R +6 more
europepmc +2 more sources
Time-Series Structural Studies of Topaquinone Biogenesis in Copper Containing Amine Oxidase
Nihon Kessho Gakkaishi, 2003 Copper-containing amine oxidase contains a covalently bound organic cofactor, 2, 4, 5-trihydroxyphenylalanine (topa) quinone, which is formed by post-translational modification of a specific tyrosine residue in the presence of copper ion and oxygen molecule. Apo-enzyme crystals were anaerobically soaked in the mother liquor that contains copper ion and
Hiroshi Yamaguchi, Misa Kim
openalex +3 more sources
The Scientific World Journal, 2014 Aliphatic amines, including methylamine, are air-pollutants, due to their intensive use in industry and the natural degradation of proteins, amino acids, and other nitrogen-containing compounds in biological samples.
Sasi Sigawi +5 more
doaj +1 more source
Frontiers in Genetics, 2023 Introduction: The amine oxidase copper-containing 1 (AOC1) gene encodes for the diamine oxidase (DAO) enzyme. DAO is an enzyme that catabolizes some molecules, including histamine, and is the degradative enzyme in the polyamine catabolic pathway that is ...
Gülşah Okutan +11 more
doaj +1 more source
BMC Genomics, 2023 Background The detection of selective traits in different populations can not only reveal current mechanisms of artificial selection for breeding, but also provide new insights into phenotypic variation in new varieties and the search for genes ...
Huibin Shi +6 more
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