Results 41 to 50 of about 16,079 (234)

Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs

open access: yesOpen Life Sciences, 2021
Vascular hyporesponsiveness in the shock decompensation period is an important factor leading to death. Myosin light chain 20 (MLC20) is the main effector protein that regulates vascular reactivity.
Zhang Yuxing   +5 more
doaj   +1 more source

Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis via Inhibition of AOC1

open access: yesFrontiers in Pharmacology, 2021
Ulcerative colitis (UC), a chronic, nonspecific inflammatory bowel disease characterized by continuous and diffuse inflammatory changes in the colonic mucosa, requires novel treatment method.
Yumei Rong   +5 more
doaj   +1 more source

Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. [PDF]

open access: yesPLoS Biology, 2018
Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown.
Haojun Yang   +9 more
doaj   +1 more source

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue

open access: yesMedicines, 2020
Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase.
Wiem Haj Ahmed   +8 more
doaj   +1 more source

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

open access: yesBiomedicines, 2023
Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Gülşah Okutan   +8 more
doaj   +1 more source

Electrochemical tuning of alcohol oxidase and dehydrogenase catalysis via biosensing towards butanol-1 detection in fermentation media [PDF]

open access: yesBiosensors and Bioelectronics 170 (2020) 112702, 2021
A novel approach for electrochemical tuning of alcohol oxidase (AOx) and alcohol dehydrogenase (ADH) biocatalysis towards butanol-1 oxidation by incorporating enzymes in various designs of amperometric biosensors is presented. The biosensors were developed by using commercial graphene oxide-based screen-printed electrodes and varying enzyme producing ...
arxiv   +1 more source

CsCuAOs and CsAMADH1 Are Required for Putrescine-Derived γ-Aminobutyric Acid Accumulation in Tea

open access: yesFoods, 2022
Polyamines are a potential source of γ-aminobutyric acid (GABA) in plants under abiotic stress. However, studies on GABA enrichment in tea mostly focus on the GABA shunt, while the correlation between polyamine degradation and GABA formation in tea is ...
Kexin Zhang   +10 more
doaj   +1 more source

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

open access: yesBiomedicines, 2021
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth   +17 more
doaj   +1 more source

SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer

open access: yesCell Death and Disease, 2022
Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer.
Yinghui Ding   +10 more
doaj   +1 more source

Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study

open access: yesFrontiers in Genetics, 2023
Introduction: The amine oxidase copper-containing 1 (AOC1) gene encodes for the diamine oxidase (DAO) enzyme. DAO is an enzyme that catabolizes some molecules, including histamine, and is the degradative enzyme in the polyamine catabolic pathway that is ...
Gülşah Okutan   +11 more
doaj   +1 more source

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