Results 61 to 70 of about 1,964,821 (266)
Editorial: Exploring and expanding the protein universe with non-canonical amino acids
Frontiers in Molecular Biosciences, 2023 Gustavo Fuertes +2 more
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Oxidant-Mediated Protein Amino Acid Conversion
Antioxidants, 2019 Biological oxidation plays important roles in the pathogenesis of various diseases and aging. Carbonylation is one mode of protein oxidation. It has been reported that amino acids that are susceptible to carbonylation are arginine (Arg), proline (Pro ...
Yuichiro J. Suzuki
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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Amino acid requirements of the infant: the amino acid composition of human breast milk
Frontiers in NutritionThe recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis.
Paul J. Moughan +10 more
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Lysosomal Amino Acid Efflux Assay
Bio-Protocol, 2014 As the cellular “recycling” organelle, lysosomes break down proteins into amino acids, which are then transported into cytosol for reuse by various amino acid transporters.
Chunlei Cang, Dejian Ren
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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Amino acid-responsive Crohn's disease: a case study
Clinical and Experimental Gastroenterology, 2010 Alvin Stein1, Marty Hinz2, Thomas Uncini31Stein Orthopedic Associates, Plantation, FL, USA; 2Clinical Research, NeuroResearch Clinics Inc., Cape Coral, FL, USA; 3Laboratory, Fairview Regional Medical Center-Mesabi, Hibbing, MN, USAPurpose: This paper ...
Alvin Stein, Marty Hinz, Thomas Uncini
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Determination methods and influencing factors of ileal endogenous amino acid losses in poultry
Siliao yanjiu, 2023 Amino acid digestibility is an important aspect to evaluate the nutritional value of feed protein in poultry. It is important to evaluate amino acid digestibility for accurate poultry feeding.
HANG Zhen-yu +3 more
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