Results 81 to 90 of about 2,226,397 (316)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Amino Acid Racemase Enzyme Assays
Bio-Protocol, 2014 Amino acid racemases are enzymes that invert the α-carbon stereochemistry of amino acids (AAs), interconverting amino acids between their L- and D-enantiomers in a reversible reaction. In bacteria, they are known to have catabolic physiological functions
Atanas Radkov, Luke Moe
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Editorial: Exploring and expanding the protein universe with non-canonical amino acids
Frontiers in Molecular Biosciences, 2023 Gustavo Fuertes +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
AN EVALUATION OF THE EFG GROWTH MODEL IN ITS CAPACITY TO PREDICT AMINO ACID REQUIREMENTS IN BROILERS [PDF]
, 2010 An experiment imposing the multi continuous phase feeding was carried out to evaluate the EFG (Emman, Fisher and Gous) Growth Model in its capacity to predict amino acid requirements in broilers. Birds were fed using blended summit (247.91g/kg CP, 3200
Indarsih, B, Pym, RAE
core
The use of mutants and transgenic plants to study amino acid metabolism.
, 1994 Mutants of higher plants with alterations in amino acid metabolism have now been available for 20 years. Following the realization that at least four distinct classes of herbicides (phosphinothricins, glyphosates, imidazolinones and sulphonylureas) act ...
P. J. LEA +3 more
core +1 more source
Amino acid requirements of the infant: the amino acid composition of human breast milk
Frontiers in NutritionThe recommended amino acid requirements of the infant are based on the amino acid composition of mature human breast milk. The amino acid composition of breast milk is usually determined following either acid or alkaline (for tryptophan) hydrolysis.
Paul J. Moughan +10 more
doaj +1 more source
Lysosomal Amino Acid Efflux Assay
Bio-Protocol, 2014 As the cellular “recycling” organelle, lysosomes break down proteins into amino acids, which are then transported into cytosol for reuse by various amino acid transporters.
Chunlei Cang, Dejian Ren
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source