Results 51 to 60 of about 2,226,397 (316)

Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism

Clinical Nutrition Open Science, 2021
Summary: Dietary amino acid absorption kinetics are an important determinant of protein quality. The term “amino acid digestibility” is commonly used to refer to the amount of ingested amino acids that become available following absorption.
Jorn Trommelen, Daniel Tomé, Luc J.C. van Loon   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Methionine to cystine ratio in the total sulfur amino acid requirements and sulfur amino acid metabolism using labelled amino acid approach for broilers

BMC Veterinary Research, 2018
Background Assuming that part of Methionine (Met) is converted into Cystine (Cys), but ignoring the rates with which such phenomenon occurs may lead to an excessive supply of Met in poultry diets.
Letícia G. Pacheco, Nilva K. Sakomura, Rafael M. Suzuki, Juliano C. P. Dorigam, Gabriel S. Viana, Jaap Van Milgen, Juliana C. Denadai   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

AMINO ACID DIGESTIBILITIES OF PALM KERNEL MEAL IN POULTRY [PDF]

, 2008
Palm kernel meal (PKM) is produced in large quantities in many parts of the world. Problems associated with PKM are due to their high fibre content, imbalanced amino acid ratios, the possibility of Maillard products and their own physical ...
Kumar, A, Dingle, J, Sundu, B
core  

Some bee-pollinated plants provide nutritionally incomplete pollen amino acid resources to their pollinators.

PLoS ONE, 2022
For pollinators such as bees, nectar mainly provides carbohydrates and pollen provides proteins, amino acids, and lipids to cover their nutritional needs. Here, to examine differences in pollinator resources, we compared the amino acid profiles and total
Léna Jeannerod, Archibald Carlier, Bertrand Schatz, Clothilde Daise, Aurore Richel, Yannick Agnan, Mathilde Baude, Anne-Laure Jacquemart   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Amino Acid Transporters on Amino Acid Absorption, Transport and Distribution in Crops

Horticulturae
Amino acid transporters mediate amino acid transport within and between cells and are the main mediators of nitrogen distribution in plants, which is crucial for maintaining plant growth and development.
Lu Liu, Xianchang Yu, Yan Yan, Chaoxing He, Jun Wang, Mintao Sun, Yansu Li   +6 more
doaj   +1 more source