Results 1 to 10 of about 1,085,115 (255)

Amino Acid Metabolism in Lupus [PDF]

Frontiers in Immunology, 2021
T cell metabolism is central to cell proliferation, survival, differentiation, and aberrations have been linked to the pathophysiology of systemic autoimmune diseases.
Michihito Kono, Nobuya Yoshida, George C. Tsokos   +2 more
doaj   +4 more sources

Effects of parthenolide on amino acid metabolism and oxidative stress in lung adenocarcinoma based on quantitative proteomic analysis, targeted amino acid metabolomics, network pharmacology, and experimental validation [PDF]

Frontiers in Oncology
BackgroundLung adenocarcinoma (LUAD) causes millions of deaths annually worldwide. Parthenolide (PTL), extracted from traditional Chinese herbal medicines, has various biological activities. In this study, we investigated the effects of PTL on amino acid
Jiye Liu, Jiye Liu, Yu Liu, Jiachun Li, Shuang Shen   +4 more
doaj   +2 more sources

Metabolism of Amino Acids in Cancer [PDF]

Frontiers in Cell and Developmental Biology, 2021
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress.
Wei Yu, Zhen Wei, Ping Yi, Chunming Cheng, Xiaoyi Liu   +4 more
openaire   +4 more sources

Amino Acid Metabolism in Apicomplexan Parasites

Metabolites, 2021
Obligate intracellular pathogens have coevolved with their host, leading to clever strategies to access nutrients, to combat the host’s immune response, and to establish a safe niche for intracellular replication.
Aarti Krishnan, Dominique Soldati-Favre
doaj   +1 more source

Amino acid metabolism in health and disease

Signal Transduction and Targeted Therapy, 2023
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function.
Zhe-Nan Ling, Yi-Fan Jiang, Jun-Nan Ru, Jia-Hua Lu, Bo Ding, Jian Wu   +5 more
doaj   +1 more source

Amino acid metabolism in skeletal cells

Bone Reports, 2022
Amino acid metabolism regulates essential cellular functions, not only by fueling protein synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids.
Claire-Sophie Devignes, Geert Carmeliet, Steve Stegen   +2 more
doaj   +1 more source

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source

Exercise Metabolome: Insights for Health and Performance

Metabolites, 2023
Exercise has many benefits for physical and mental well-being. Metabolomics research has allowed scientists to study the impact of exercise on the body by analyzing metabolites released by tissues such as skeletal muscle, bone, and the liver.
Aayami Jaguri, Asmaa A. Al Thani, Mohamed A. Elrayess   +2 more
doaj   +1 more source

Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy.
Yue Zheng, Yiran Yao, Tongxin Ge, Shengfang Ge, Renbing Jia, Xin Song, Ai Zhuang   +6 more
doaj   +1 more source

Identification of an amino acid metabolism-associated gene signature predicting the prognosis and immune therapy response of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
BackgroundThe upregulation of amino acid metabolism is an essential form of metabolic reprogramming in cancer. Here, we developed an amino acid metabolism signature to predict prognosis and anti-PD-1 therapy response in clear cell renal cell carcinoma ...
Fan Zhang, Junyu Lin, Daiwen Zhu, Yongquan Tang, Yiping Lu, Zhihong Liu, Xianding Wang   +6 more
doaj   +1 more source