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The effect of fructose exposure on amino acid metabolism among Chinese community residents and its possible multi-omics mechanisms [PDF]

Scientific Reports, 2023
The consumption of fructose has increased dramaticly during the last few decades, inducing a great increase in the risk of intrahepatic lipid accumulation, hypertriglyceridemia, hyperuricemia and cancer. However, the underlying mechanism has not yet been
Ouyan Rang, Xinru Qin, Yonghong Tang, Lin Cao, Guojuan Li, Xiaocheng Liu, Jing Zhong, Mu Wang   +7 more
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Amino Acid Metabolism in Lupus

Frontiers in Immunology, 2021
T cell metabolism is central to cell proliferation, survival, differentiation, and aberrations have been linked to the pathophysiology of systemic autoimmune diseases.
Michihito Kono, Nobuya Yoshida, George C. Tsokos   +2 more
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Amino Acid Metabolism in Apicomplexan Parasites

Metabolites, 2021
Obligate intracellular pathogens have coevolved with their host, leading to clever strategies to access nutrients, to combat the host’s immune response, and to establish a safe niche for intracellular replication.
Aarti Krishnan, Dominique Soldati-Favre
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Amino acid metabolism in health and disease

Signal Transduction and Targeted Therapy, 2023
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function.
Zhe-Nan Ling, Yi-Fan Jiang, Jun-Nan Ru, Jia-Hua Lu, Bo Ding, Jian Wu   +5 more
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Amino acid metabolism in skeletal cells

Bone Reports, 2022
Amino acid metabolism regulates essential cellular functions, not only by fueling protein synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids.
Claire-Sophie Devignes, Geert Carmeliet, Steve Stegen   +2 more
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Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
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Exercise Metabolome: Insights for Health and Performance

Metabolites, 2023
Exercise has many benefits for physical and mental well-being. Metabolomics research has allowed scientists to study the impact of exercise on the body by analyzing metabolites released by tissues such as skeletal muscle, bone, and the liver.
Aayami Jaguri, Asmaa A. Al Thani, Mohamed A. Elrayess   +2 more
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Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy.
Yue Zheng, Yiran Yao, Tongxin Ge, Shengfang Ge, Renbing Jia, Xin Song, Ai Zhuang   +6 more
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Identification of an amino acid metabolism-associated gene signature predicting the prognosis and immune therapy response of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
BackgroundThe upregulation of amino acid metabolism is an essential form of metabolic reprogramming in cancer. Here, we developed an amino acid metabolism signature to predict prognosis and anti-PD-1 therapy response in clear cell renal cell carcinoma ...
Fan Zhang, Junyu Lin, Daiwen Zhu, Yongquan Tang, Yiping Lu, Zhihong Liu, Xianding Wang   +6 more
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Oncology Therapeutics Targeting the Metabolism of Amino Acids

Cells, 2020
Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion.
Nefertiti Muhammad, Hyun Min Lee, Jiyeon Kim   +2 more
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