Results 41 to 50 of about 4,195,373 (294)

Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review

Frontiers in Immunology
The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism and immune system components within the tumor microenvironment have elucidated the functional ...
Yuchun Jiang, Qing Tao, Xuehan Qiao, Yufei Yang, Chen Peng, Miao Han, Kebin Dong, Wei Zhang, Min Xu, Deqiang Wang, Deqiang Wang, Wen Zhu, Xiaoqin Li   +12 more
doaj   +1 more source

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

eLife, 2021
Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms.
Leonie Zeitler, Alessandra Fiore, Claudia Meyer, Marion Russier, Gaia Zanella, Sabine Suppmann, Marco Gargaro, Sachdev S Sidhu, Somasekar Seshagiri, Caspar Ohnmacht, Thomas Köcher, Francesca Fallarino, Andreas Linkermann, Peter J Murray   +13 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Amino Acids and Their Metabolism in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
As a leading cause of death worldwide, cardiovascular disease is a global health concern. The development and progression of atherosclerosis, which ultimately gives rise to cardiovascular disease, has been causally linked to hypercholesterolemia.
Katrin, Nitz, Michael, Lacy, Dorothee, Atzler   +2 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism

Clinical Nutrition Open Science, 2021
Summary: Dietary amino acid absorption kinetics are an important determinant of protein quality. The term “amino acid digestibility” is commonly used to refer to the amount of ingested amino acids that become available following absorption.
Jorn Trommelen, Daniel Tomé, Luc J.C. van Loon   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

AMINO ACID PROFIL OF EARTHWORM AND EARTHWORM M AL (Lumbricus rubellus )FOR ANIMAL F DSTUFF [PDF]

, 2009
Earthworm meal (Lumbricus rubellus has become one of natural material that could be used as feed additive.Powdering method of earthworm was done by using formic acid addition.The study was carried out (1)to evaluate the essential amino acid profile of ...
Sofyan, A, Damayanti, E, Julendra, H, Istiqomah, L   +3 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Changes of fatty acid metabolism and oxidative phosphorylation of rat liver mitochondria during 3'-Me-DAB feeding [PDF]

, 1964
Respiration, activity of oleate oxidation and composition of the total fatty acids of rat liver were investigated in 3'-Me-DAB feeding. 1. Oxidative phosphorylation of rat liver mitochondria decreased temporarily at relatively earlier stages (about 2 to ...
Inaba, Kozo
core   +1 more source