Results 61 to 70 of about 4,195,373 (294)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Amino Acid Catabolism: An Overlooked Area of Metabolism

, 2023
Amino acids have been extensively studied in nutrition, mainly as key elements for maintaining optimal protein synthesis in the body as well as precursors of various nitrogen-containing compounds. However, it is now known that amino acid catabolism is an
Laura A. Velazquez-Villegas, Gabriela Alemán-Escondrillas, Armando R. Tovar, Sandra Tobón-Cornejo, Nimbe Torres, Lilia G. Noriega   +5 more
core   +1 more source

Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens

Frontiers in Nutrition, 2022
Non-alcoholic fatty liver disease (NAFLD) is a chronic and metabolic liver disease and commonly occurs in humans with obesity and type 2 diabetes mellitus (T2DM); such a condition also exists in animals such as rodents and laying hens.
Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Yan Li, Yan Li, Yan Li, Yan Li, Yan Li, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou   +44 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dietary Intake and Circulating Amino Acid Concentrations in Relation with Bone Metabolism Markers in Children Following Vegetarian and Omnivorous Diets

, 2023
Scientific studies reported that most vegetarians meet the total protein requirements; however, little is known about their amino acid intakes. We aimed to assess dietary intake and serum amino acid levels in relation to bone metabolism markers in ...
Jadwiga Ambroszkiewicz, Joanna Gajewska, Małgorzata Strucińska, Katarzyna Kuśmierska, Grażyna Rowicka, Joanna Mazur, Magdalena Chełchowska, Witold Klemarczyk   +7 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Developments in plant breeding for improved nutritional quality of soya beans I. Protein and amino acid content [PDF]

, 2000
Soya beans, like other legumes, contain low concentrations of the nutritionally essential sulphur amino acid, methionine. Cysteine, although not an essential amino acid because it can be synthesized from methionine, also influences the nutritional ...
Clarke, E, Wiseman, J
core  

Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells. [PDF]

, 2010
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount of information concerning their metabolic potential.
Götz Andreas, Götz, Andreas, Eylert, Eva, Eylert Eva, Werner Goebel, Goebel, Werner, Eva Eylert, Eisenreich, Wolfgang, Goetz, Andreas, Andreas Götz, Wolfgang Eisenreich, Eisenreich Wolfgang, Goebel Werner   +12 more
core   +2 more sources