Results 51 to 60 of about 4,195,373 (294)

Research progress on branched-chain amino acid aminotransferases

Frontiers in Genetics, 2023
Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells.
Can Chen, Hassan Naveed, Hassan Naveed, Keping Chen   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Targeting pivotal amino acids metabolism for treatment of leukemia

Heliyon
Metabolic reprogramming is a crucial characteristic of cancer, allowing cancer cells to acquire metabolic properties that support their survival, immune evasion, and uncontrolled proliferation.
Jiankun Hong, Wuling Liu, Xiao Xiao, Babu Gajendran, Yaacov Ben-David   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis [PDF]

, 2013
The beet cyst nematode Heterodera schachtii is able to infect Arabidopsis plants and induce feeding sites in the root. These syncytia are the only source of nutrients for the nematodes throughout their life and are a nutrient sink for the host plant.
Elashry, Abdelnaser, Siddique, Shahid, Koch, Wolfgang, Kreil, David, Okumoto, Sakiko, Bohlmann, Holger, Kreil, David P.   +6 more
core   +1 more source

Amino acid metabolic reprogramming by gut microbiota: a novel metabolic checkpoint in the tumor microenvironment

Gut Microbes
The gut microbiota plays a crucial role in human health, significantly influencing various physiological functions such as amino acid metabolism, which is essential for maintaining homeostasis and preventing disease.
Huiyu Lin, Xiya Deng, Yating Yang, Ruoyan Zhang, Yan-Dong Wang, Wei-Dong Chen   +5 more
doaj   +1 more source

Transcriptomic Responses Induced in Muscle and Adipose Tissues of Growing Pigs by Intravenous Infusion of Sodium Butyrate

Biology, 2021
Butyrate has a central function in the regulation of energy metabolism as a metabolite of bacterial fermentation. This study evaluated the effects of intravenous sodium butyrate (SB) administration on the transcriptome of muscle and adipose tissue of ...
He Zhang, Erdu Ren, Rongying Xu, Yong Su
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Amino acid transporter genes are essential for FLO11-dependent and FLO11-independent biofilm formation and invasive growth in saccharomyces cerevisiae [PDF]

, 2012
Amino acids can induce yeast cell adhesion but how amino acids are sensed and signal the modulation of the FLO adhesion genes is not clear. We discovered that the budding yeast Saccharomyces cerevisiae CEN.PK evolved invasive growth ability under ...
Eckhard Boles, Sefa Alizadeh, Eckhard Boles (148580), Henrik Devitt Møller (148562), Møller, Henrik Devitt, Doreen Ochmann (148576), Møller, Henrik D., Gresham, David, Ochmann, Doreen, Doreen Ochmann, Torbensen, Rasmus, Birgitte Regenberg, Rasmus Torbensen, David Gresham (148568), Boles, Eckhard, Regenberg, Birgitte, Henrik Devitt Møller, Birgitte Regenberg (24433), Rasmus Torbensen (148554), Sefa Alizadeh (148573), Alizadeh, Sefa, David Gresham   +21 more
core   +2 more sources

The metabolism of “surplus” amino acids [PDF]

British Journal of Nutrition, 2012
For an adult in N balance, apart from small amounts of amino acids required for the synthesis of neurotransmitters, hormones, etc, an amount of amino acids almost equal to that absorbed from the diet can be considered to be “surplus” in that it will be catabolized.
openaire   +2 more sources