Results 21 to 30 of about 683,558 (264)

Amino acid metabolism in primary bone sarcomas

Frontiers in Oncology, 2022
Primary bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive tumors with peak incidence in childhood and adolescence. The intense standard treatment for these patients consists of combined surgery and/or radiation and maximal
Jennifer A. Jiménez, Jennifer A. Jiménez, Elizabeth R. Lawlor, Elizabeth R. Lawlor, Costas A. Lyssiotis, Costas A. Lyssiotis, Costas A. Lyssiotis   +6 more
doaj   +1 more source

Amino Acid Metabolism in Cancer Drug Resistance

Cells, 2022
Despite the numerous investigations on resistance mechanisms, drug resistance in cancer therapies still limits favorable outcomes in cancer patients.
Hee-Chan Yoo, Jung-Min Han
doaj   +1 more source

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Cells, 2020
Function of brain amino acids as neurotransmitters or their precursors implies changes in the amino acid levels and/or metabolism in response to physiological and environmental challenges.
Anastasia Graf, Lidia Trofimova, Alexander Ksenofontov, Lyudmila Baratova, Victoria Bunik   +4 more
doaj   +1 more source

Fractionation, molecular composition, and biological effects of organic matter in bio-stabilization sludge with implication to land utilization

Environment International, 2022
Bioactive organic compounds (BOCs) contained in bio-stabilized products of waste activated sludge (WAS) have attracted considerable attention, as they can enhance the fertilizing effect of WAS in land applications.
Yu Zhang, Hao Yuan, Siying Cai, Hang He, Peng Yang, Aibin Hu, Weijun Zhang, Dongsheng Wang   +7 more
doaj   +1 more source

Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism

Clinical Nutrition Open Science, 2021
Summary: Dietary amino acid absorption kinetics are an important determinant of protein quality. The term “amino acid digestibility” is commonly used to refer to the amount of ingested amino acids that become available following absorption.
Jorn Trommelen, Daniel Tomé, Luc J.C. van Loon   +2 more
doaj   +1 more source

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

eLife, 2021
Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms.
Leonie Zeitler, Alessandra Fiore, Claudia Meyer, Marion Russier, Gaia Zanella, Sabine Suppmann, Marco Gargaro, Sachdev S Sidhu, Somasekar Seshagiri, Caspar Ohnmacht, Thomas Köcher, Francesca Fallarino, Andreas Linkermann, Peter J Murray   +13 more
doaj   +1 more source

Targeting amino acid in tumor therapy

Frontiers in Oncology
Tumor cells undergo profound metabolic reprogramming to sustain their rapid growth and proliferation, with amino acids serving as essential nutrients critical for protein synthesis, energy metabolism, nucleotide production, and redox balance.
Mingpai Ge, Yuan Xu, Lu Cui, Enyuan Huang, Zhaorui Liu, Kai Yin   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review

Frontiers in Immunology
The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism and immune system components within the tumor microenvironment have elucidated the functional ...
Yuchun Jiang, Qing Tao, Xuehan Qiao, Yufei Yang, Chen Peng, Miao Han, Kebin Dong, Wei Zhang, Min Xu, Deqiang Wang, Deqiang Wang, Wen Zhu, Xiaoqin Li   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source