Results 11 to 20 of about 4,195,373 (294)

Oncology Therapeutics Targeting the Metabolism of Amino Acids

Cells, 2020
Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion.
Nefertiti Muhammad, Hyun Min Lee, Jiyeon Kim   +2 more
doaj   +2 more sources

Amino Acid Metabolism in Cancer Drug Resistance

Cells, 2022
Despite the numerous investigations on resistance mechanisms, drug resistance in cancer therapies still limits favorable outcomes in cancer patients.
Hee-Chan Yoo, Jung-Min Han
doaj   +2 more sources

Amino Acid Metabolism and Disease

International Journal of Molecular Sciences, 2023
The origin of life is still a matter of debate, and several hypotheses have been proposed to explain how the building blocks leading to the minimal cell were formed [...]
Pajares, María Ángeles, María Ángeles Pajares   +1 more
openaire   +4 more sources

Amino Acid Metabolism

Annual Review of Plant Physiology, 1977
Miflin, B. J., Lea, P. J.
openaire   +2 more sources

Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism [PDF]

, 2022
Enzymes involved in Staphylococcus aureus amino acid metabolism have recently gained traction as promising targets for the development of new antibiotics, however, not all aspects of this process are understood. The ATP-grasp superfamily includes enzymes
Bruning, John B., Pederick, JL, Abell, AD, Jovcevski‬, Blagojce, Klose, J, Bruning, JB, Klose, Jack, Pukala, TL, Horsfall, AJ, Abell, Andrew D., Pukala, Tara L., Pederick, Jordan L., Horsfall, Aimee J., Jovcevski‬, B   +13 more
core   +1 more source

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source

Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy.
Yue Zheng, Yiran Yao, Tongxin Ge, Shengfang Ge, Renbing Jia, Xin Song, Ai Zhuang   +6 more
doaj   +1 more source

Exercise Metabolome: Insights for Health and Performance

Metabolites, 2023
Exercise has many benefits for physical and mental well-being. Metabolomics research has allowed scientists to study the impact of exercise on the body by analyzing metabolites released by tissues such as skeletal muscle, bone, and the liver.
Aayami Jaguri, Asmaa A. Al Thani, Mohamed A. Elrayess   +2 more
doaj   +1 more source

A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffected [PDF]

, 2010
The aim of this study was to investigate the role of the amino acid permease gene AAP6 in regulating phloem amino acid composition and then to determine the effects of this altered diet on aphid performance.
Newbury, H. J., Hunt, E. (Emma), Gattolin, Stefano, Pritchard, J. (Jeremy), Tseng, Hua-Ming, Bale, J. S. (Jeffrey S.), Barrett, D. A. (David A.)   +6 more
core   +2 more sources

Identification of an amino acid metabolism-associated gene signature predicting the prognosis and immune therapy response of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
BackgroundThe upregulation of amino acid metabolism is an essential form of metabolic reprogramming in cancer. Here, we developed an amino acid metabolism signature to predict prognosis and anti-PD-1 therapy response in clear cell renal cell carcinoma ...
Fan Zhang, Junyu Lin, Daiwen Zhu, Yongquan Tang, Yiping Lu, Zhihong Liu, Xianding Wang   +6 more
doaj   +1 more source