Results 51 to 60 of about 585 (187)

Carnitine : analytical and physiological aspects [PDF]

, 2012
Carnitine is an endogenous amino acid derivative which plays a key role in energy metabolism. Through acylation of its ß-hydroxy group, carnitine is involved in the interorganellar transport of long-chain fatty acids and in the regulation of the coenzyme
Bourqui, Réjane Morand
core   +1 more source

Controversies in Parenteral Protein Intake in Preterm Infants

Children
As the limit of viability is extended to lower gestational ages, neonatologists caring for preterm infants must discover the optimal nutritional combination to support postnatal growth.
Ira Holla, Pradeep Alur
doaj   +1 more source

Diagnosis and therapeutic monitoring of inborn errors of metabolism in 100,077 newborns from Jining city in China

BMC Pediatrics, 2018
Background Mandatory newborn screening for metabolic disorders has not been implemented in most parts of China. Newborn mortality and morbidity could be markedly reduced by early diagnosis and treatment of inborn errors of metabolism (IEM).
Chi-Ju Yang, Na Wei, Ming Li, Kun Xie, Jian-Qiu Li, Cheng-Gang Huang, Yong-Sheng Xiao, Wen-Hua Liu, Xi-Gui Chen   +8 more
doaj   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Automated Tandem Mass Spectrometry for Mass Newborn Screening for Disorders in Fatty Acid, Organic Acid, and Amino Acid Metabolism

, 1999
Development of acylcarnitine and amino acid profiling using tandem mass spectrometry, and its application for use with dried blood specimens collected on filter-paper cards, has introduced an innovative new technology for detecting inborn errors of fatty
Edwin W. Naylor, Donald H. Chace
core   +1 more source

The importance of plasma amino acid profiling in the diagnosis of inborn errors of metabolism: analytical – prospective study [PDF]

, 2022
Introducere. Erorile înnăscute de metabolism (EIM) alcătuiesc un grup larg de tulburări cauzate de un defect genetic al proteinelor care au rol enzimatic, de transport, receptor sau structural.
Efremov, Egor, Blăniță, Daniela, Deleanu, Calin, Hlistun, Victoria, Boiciuc, Chiril, Nicolescu, Alina, Ușurelu, Natalia   +6 more
core  

Maternal and umbilical cord plasma concentrations of antiseizure medications: Results from the observational MONEAD study

Epilepsia, EarlyView.
Abstract Objective Unanticipated changes in antiseizure medication (ASM) exposure can lead to subtherapeutic or toxic medication concentrations in the mother and unnecessary drug exposure for the fetus. The objectives of this study were to characterize ASM concentrations in mother's and cord blood at delivery in women with epilepsy (PWWE).
Charul Avachat, Kimford J. Meador, Page B. Pennell, Angela K. Birnbaum, MONEAD Investigator Group, Delmaris Acosta‐Cotte, Sandra Alhaj, Stephanie Allien, Taimur Anwar, Anto Bagic, Gregory L. Barkley, Donald Bearden, Susan Beers, Irena Bellinski, Christin Bermudez, Kristina Blessing, Katrina Boyer, Camilla Casadei, Patricia Chang, Li Chen, Andrea Cheng‐Hakimian, Melanie Choe, Kirsten Cleary, Tobi Clements, Joseph Coda, Pam Coe, Jules Constantinou, Yael Cukier Cukier, Danielle Culbreth, Elizabeth Cunningham, Kayla Darris, Lisa Davis, Rosemarie Delucca, Jennifer DeWolfe, Jessica Dimos, Mary Dolan, Maurice Druzin, Joyce Echo, Sarah Ellis, Pedro Figueredo, Richard Finnell, Kellie Flood‐Schaffer, Jacqueline French, Mark Friedman, Shailaja Gaddam, Satya Gedela, Elizabeth Garard, Christine Ghilian, William Grobman, Cheryl Hall, Ellen Hanson, Jacqueline Helcer Helcer, Paige Hickey, Gregory Holmes, Theresa Holmes, Dominic Ippolito, George Jewell, Arundhathi Jeyabalan, Emily Johnson, Michelle Kim, Gregory Krauss, Casey Krueger, David Labiner, Hadley Lange, Erin Latif, Connie Lau Lau, Shari Lawson, Brenda Leung, William MacAllister, James Maciulla, Hayley Madeiros, Nazin Mahmood, Jennie Mao, Ryan May, Paul McCabe, Frederick T. McElrath, Erica Meltzer Meltzer, Lucy Mendoza, Emily Miller, John W. Miller, Michelle Miranda, Jennifer Moon, Eugene Moore, Melissa Morris, Chris Morrison, Lorene Nelson, Melanee Newman, Alisha Olson, Kim Ono, John Owen, Alison Pack, Michael Paglia, Yong Park, Lamar Parker, Christina Patterson, Sonia Perez, Jenny Pohlman, Alison Pritchard, Michael Privitera, Krestin Radonovich, Patty Ray, Katie Reger, Gustavo Rey, Matthew Ryan, Yasin Salih, Carla Sandles, William Schweizer, Jordan Seliger, Enrique Serrano, Nilay Shah, Elizabeth Shashkova, Traci Sheer, Yvonne Sheldon, Rachel Sierra, Marianna Spanaki‐Varelas, Anna Steele, Jennifer Steele, Alice Stek, Zachary Stowe, Jolie Strauss, Suzanne Strickland, Melissa Sutcliffe, Hima Bindu Tam Tam, Diane Teagarden, Andrea Thomas, Matthew Thompson, Jeffery Tsai, Alexandra Urban, Linda Van Marter, Naymee Velez‐Ruiz, Yue Wang, Vibhangini Wasade, Taylor Weinau, Peter Wells, Carrie Wiles, Mark Yerby, Amy Young, Andrew Zillgitt, Annette Zygmunt   +138 more
wiley   +1 more source

3-Hydroxy-3-methylglutaryl coenzyme A lyase: targeting and processing in peroxisomes and mitochondria

Journal of Lipid Research, 1999
3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL, E.C. 4.1.3.4) has a unique dual localization in both mitochondria and peroxisomes. Mitochondrial HL (~31.0 kDa) catalyzes the last step of ketogenesis; the function of peroxisomal HL (~33.5 kDa) is unknown.
Lyudmila I. Ashmarina, Alexey V. Pshezhetsky, Steven S. Branda, Grazia Isaya, Grant A. Mitchell   +4 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source