Oncology Therapeutics Targeting the Metabolism of Amino Acids
Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion.
Nefertiti Muhammad+2 more
doaj +1 more source
Infantile hemangioma (IH) is the most common benign tumor in children. However, the exact pathogenesis of IH remains unclear. Integrated nontargeted and targeted metabolic analyses were performed to obtain insight into the possible pathogenic mechanism ...
Kaiying Yang+7 more
doaj +1 more source
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel+4 more
core +1 more source
Research Progress of Amino Acid Metabolism PET Imaging in Tumor
Amino acid metabolism PET imaging plays a very important role in metabolism molecular imaging. Amino acid PET tracers include [1-11C]amino acid, labeling α-C amino acid, labeling side-chain amino acid, and N-substituted labeling amino acid.
NIE Da-hong, TANG Gang-hua2
doaj +1 more source
Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function [PDF]
Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer.In 16 patients with advanced cancer undergoing ...
Deutz, Nicolaas E P+3 more
core +1 more source
Connections Between Amino Acid Metabolisms in Plants: Lysine as an Example
Extensive efforts have been made to fortify essential amino acids and boost nutrition in plants, but unintended effects on growth and physiology are also observed.
Qingqing Yang+4 more
doaj +1 more source
Multi-Omics Data Reveal Amino Acids Related Genes in the Common Carp Cyprinus carpio
Amino acids have important physiological effects on fish growth and development and are essential nutrition for humans. Flavor-related amino acids, such as glutamic acid and glycine, could have a significant effect on the taste of fish flesh.
Hanyuan Zhang+8 more
doaj +1 more source
Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring. [PDF]
Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid ...
Han, Anna, Kwon, Young Hye, Won, Sae Bom
core +3 more sources
The present study aimed to develop an isotope protocol to achieve equilibrium of 13CO2 in breath of cats during carbon oxidation studies using L-[1-13C]-Phenylalanine (L-[1-13C]-Phe), provided orally in repeated meals.
Julia Guazzelli Pezzali+3 more
doaj +1 more source
Regulatory effects of blood constituents on the function and metabolism of the cat brain in perfusion ezperiments. Brain perfusion with artificial blood containing low molecular dextran and amino acids [PDF]
As a link in a series of studies on the effects of blood constituents on the brain function by means of brain perfusion, we used four kinds of artificial blood; namely, the blood containing a low molecular dextran, one containing glutamic acid, one ...
Edamatsu, Kazuyasu+5 more
core +1 more source