Results 31 to 40 of about 657,471 (210)

Targeting pivotal amino acids metabolism for treatment of leukemia

Heliyon
Metabolic reprogramming is a crucial characteristic of cancer, allowing cancer cells to acquire metabolic properties that support their survival, immune evasion, and uncontrolled proliferation.
Jiankun Hong, Wuling Liu, Xiao Xiao, Babu Gajendran, Yaacov Ben-David   +4 more
doaj   +1 more source

Astrocyte metabolism and signaling pathways in the CNS

Frontiers in Neuroscience, 2023
Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression ...
Yong-mei Zhang, Yong-mei Zhang, Yong-mei Zhang, Ying-bei Qi, Ying-bei Qi, Ying-bei Qi, Ya-nan Gao, Ya-nan Gao, Wen-gang Chen, Wen-gang Chen, Ting Zhou, Ting Zhou, Yi Zang, Yi Zang, Jia Li, Jia Li, Jia Li, Jia Li   +17 more
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Role of amino acid metabolism in mitochondrial homeostasis

Frontiers in Cell and Developmental Biology, 2023
Mitochondria are central hubs for energy production, metabolism and cellular signal transduction in eukaryotic cells. Maintenance of mitochondrial homeostasis is important for cellular function and survival.
Qiaochu Li, Thorsten Hoppe, Thorsten Hoppe   +2 more
doaj   +1 more source

The effect of fructose exposure on amino acid metabolism among Chinese community residents and its possible multi-omics mechanisms

Scientific Reports, 2023
The consumption of fructose has increased dramaticly during the last few decades, inducing a great increase in the risk of intrahepatic lipid accumulation, hypertriglyceridemia, hyperuricemia and cancer. However, the underlying mechanism has not yet been
Ouyan Rang, Xinru Qin, Yonghong Tang, Lin Cao, Guojuan Li, Xiaocheng Liu, Jing Zhong, Mu Wang   +7 more
doaj   +1 more source

AHL-differential quorum sensing regulation of amino acid metabolism in Hafnia alvei H4

Microbiology Spectrum
Quorum sensing (QS) regulation of functional metabolites is rarely reported but a common trait of some bacteria. In this study, we found that QS promoted the extracellular accumulation of glycine and serine while inhibiting the extracellular accumulation
Congyang Yan, Xue Li, Gongliang Zhang, Jingran Bi, Hongshun Hao, Hongman Hou   +5 more
doaj   +1 more source

The significant role of amino acid metabolic reprogramming in cancer

Cell Communication and Signaling
Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells is intricately linked to protein synthesis, nucleotide synthesis ...
Xiaohong Liu, Bo Ren, Jie Ren, Minzhi Gu, Lei You, Yupei Zhao   +5 more
doaj   +1 more source

Predicting post-absorptive protein and amino acid metabolism

Revista Brasileira de Zootecnia, 2018
Sustainable production of adequate quantities of food to support a growing human population is a worldwide goal. Under current feeding conditions in the United States, dairy cattle convert dietary nitrogen to milk nitrogen with 25% efficiency.
Mark D. Hanigan, Robin R. White, Sebastian I. Arriola Apelo, Michelle Aguilar, Kari A. Estes, Adelyn Myers   +5 more
doaj   +1 more source

Urinary Screening for Aminoacidurias Using Chromatography and Serum Amino Acid Profile in Type 2 Diabetes and Healthy Controls

Biochemistry Research International
Type 2 diabetes is a complex metabolic disorder characterised by altered amino acid metabolism. This study investigates plasma amino acid profiles and specific aminoacidurias in patients with type 2 diabetes.
Sushma B. J., Sumit Parashar, Balvir Singh Tomar, Alka Meena, Priyanka B. J.   +4 more
doaj   +1 more source

Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies

Frontiers in Oncology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies with an extremely poor prognosis. Energy metabolism reprogramming, an emerging hallmark of cancer, has been implicated in the tumorigenesis and development of pancreatic cancer.
Ruiyuan Xu, Jinshou Yang, Bo Ren, Huanyu Wang, Gang Yang, Yuan Chen, Lei You, Yupei Zhao   +7 more
doaj   +1 more source

Effects of parthenolide on amino acid metabolism and oxidative stress in lung adenocarcinoma based on quantitative proteomic analysis, targeted amino acid metabolomics, network pharmacology, and experimental validation

Frontiers in Oncology
BackgroundLung adenocarcinoma (LUAD) causes millions of deaths annually worldwide. Parthenolide (PTL), extracted from traditional Chinese herbal medicines, has various biological activities. In this study, we investigated the effects of PTL on amino acid
Jiye Liu, Jiye Liu, Yu Liu, Jiachun Li, Shuang Shen   +4 more
doaj   +1 more source