Results 41 to 50 of about 482,766 (258)

Targeting amino acid in tumor therapy

Frontiers in Oncology
Tumor cells undergo profound metabolic reprogramming to sustain their rapid growth and proliferation, with amino acids serving as essential nutrients critical for protein synthesis, energy metabolism, nucleotide production, and redox balance.
Mingpai Ge, Yuan Xu, Lu Cui, Enyuan Huang, Zhaorui Liu, Kai Yin   +5 more
doaj   +1 more source

Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens

Frontiers in Nutrition, 2022
Non-alcoholic fatty liver disease (NAFLD) is a chronic and metabolic liver disease and commonly occurs in humans with obesity and type 2 diabetes mellitus (T2DM); such a condition also exists in animals such as rodents and laying hens.
Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Huafeng Jian, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Qianqian Xu, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Sasa Miao, Yan Li, Yan Li, Yan Li, Yan Li, Yan Li, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Tianming Mou, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xinyang Dong, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou, Xiaoting Zou   +44 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review

Frontiers in Immunology
The incidence of gastric cancer remains high and poses a serious threat to human health. Recent comprehensive investigations into amino acid metabolism and immune system components within the tumor microenvironment have elucidated the functional ...
Yuchun Jiang, Qing Tao, Xuehan Qiao, Yufei Yang, Chen Peng, Miao Han, Kebin Dong, Wei Zhang, Min Xu, Deqiang Wang, Deqiang Wang, Wen Zhu, Xiaoqin Li   +12 more
doaj   +1 more source

Regulation of amino acid metabolism in Aphis gossypii parasitized by Binodoxys communis

Frontiers in Nutrition, 2022
The vast majority of parasitoids are capable of precise and meticulous regulation of nutrition and metabolism within the host. An important building block of life, amino acids are critical to the development of parasitoids.
Hui Xue, Hui Xue, Yunyun Zhao, Yunyun Zhao, Li Wang, Li Wang, Xiangzhen Zhu, Xiangzhen Zhu, Kaixin Zhang, Kaixin Zhang, Dongyang Li, Dongyang Li, Jichao Ji, Jichao Ji, Lin Niu, Lin Niu, Jinjie Cui, Jinjie Cui, Junyu Luo, Junyu Luo, Xueke Gao, Xueke Gao   +21 more
doaj   +1 more source

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]

, 2017
Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing, Liu, Yunxia, Shao, Jing, Sun, Haipeng, Wang, Yibin, Zhou, Meiyi   +5 more
core   +2 more sources

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Transcriptional regulation of amino acid metabolism in response to nitrogen deficiency and nitrogen forms in tea plant root (Camellia sinensis L.)

Scientific Reports, 2020
Free amino acids, including theanine, glutamine and glutamate, contribute greatly to the pleasant taste and multiple health benefits of tea. Amino acids in tea plants are mainly synthesized in roots and transported to new shoots, which are significantly ...
Tianyuan Yang, Huiping Li, Yuling Tai, Chunxia Dong, Xunmin Cheng, Enhua Xia, Ziping Chen, Fang Li, Xiaochun Wan, Zhaoliang Zhang   +9 more
doaj   +1 more source

The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid [PDF]

, 1948
A summary of the little that is known of the metabolism of lysine in animals is as follows: it is indispensable in the diet, its α-amino group does not participate in reversible transamination reaction in vivo (2), neither the L nor D form is attacked by
Borsook, Henry, Deasy, Clara L., Haagen-Smit, A. J., Keighley, Geoffrey, Lowy, Peter H.   +4 more
core   +1 more source

A stoichiometric reaction scheme for Saccharothrix algeriensis growth and thiolutin production [PDF]

, 2010
A new bacterial species, Saccharothrix algeriensis NRRL B-24137, was isolated in 1992 in the Sahara desert. This filamentous bacterium is able to produce dithiolopyrrolones, molecules presenting antibacterial, antifungal, and anticancer properties.
Brandam, Cédric, Lebrihi, Ahmed, Meyer, Xuân-Mi, Strub, Caroline   +3 more
core   +1 more source