Results 111 to 120 of about 1,713,312 (302)

aaHash: recursive amino acid sequence hashing. [PDF]

Bioinform Adv, 2023
Wong J, Kazemi P, Coombe L, Warren RL, Birol I.   +4 more
europepmc   +1 more source

Sequence homology between RNAs encoding rat α-fetoprotein and rat serum albumin [PDF]

, 1981
We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat α-fetoprotein mRNA. The resultant nucleotide sequence of α-fetoprotein was exhaustively compared to the nucleotide sequence ...
Bonner, James, Glackin, Carlotta, Jagodzinski, Linda L., Sargent, Thomas D., Yang, Maria   +4 more
core  

Amino Acid Sequence of Mung Bean Trypsin Inhibitor and Its Modified Forms Appearing during Germination [PDF]

, 1983
Karl A. Wilson, Jean C. Chen
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Accurate prediction of substitution rates at protein sites with a mutation-selection model

Scientific Reports
The pattern of substitutions at sites in proteins provides invaluable information about their biophysical and functional importance and what selection pressures are acting at individual sites.
Ingemar André
doaj   +1 more source

Mutagenesis of the conserved 51-nucleotide region of Sindbis virus [PDF]

, 1990
We have constructed 25 site-specific mutations in a domain of 51 nucleotides in Sindbis virus that is highly conserved among all alphaviruses sequenced to date.
Niesters, Hubert G. M., Strauss, James H.   +1 more
core  

Protein design in a lattice model of hydrophobic and polar amino acids

, 1997
A general strategy is described for finding which amino acid sequences have native states in a desired conformation (inverse design). The approach is used to design sequences of 48 hydrophobic and polar aminoacids on three-dimensional lattice structures.
A. Lombardi, A. Sali, Amos Maritan, C. J. Camacho, C. Pabo, Cristian Micheletti, E. I. Shakhnovich, E. I. Shakhnovich, F. Seno, Flavio Seno, H. Li, H. S. Chan, J. Bryngelson, J. M. Deutsch, J. N. Onuchic, J. U. Bowie, J. W. Ponder, Jayanth R. Banavar, K. A. Dill, K. F. Lau, K. F. Lau, K. Yue, K. Yue, K. Yue, K. Yue, M. H. J. Cordes, M. P. Morrissey, S. J. Sun, S. Kamtekar, T. P. Quinn, Y. Kuroda   +30 more
core   +1 more source

TCN-HBP: A Deep Learning Method for Identifying Hormone-Binding Proteins from Amino Acid Sequences Based on a Temporal Convolution Neural Network

, 2021
Jing Guo
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source