Results 81 to 90 of about 2,757,435 (387)

Exploring the Levinthal limit in protein folding [PDF]

, 2017
According to the thermodynamic hypothesis, the native state of proteins is uniquely defined by their amino acid sequence. On the other hand, according to Levinthal, the native state is just a local minimum of the free energy and a given amino acid ...
B Fazi, B Hess, C Anfınsen, C Levinthal, C Orengo, D Baker, D Case, D van der Spoel, H Berman, H Gouda, J Sohl, JD Bryngelson, K Dill, L Cruzeiro, L Cruzeiro, L Cruzeiro, Leonor Cruzeiro, Léo Degrève, P Gettins, T Gallagher, T Lazaridis, TR Hynes, W Humphrey, W van Gunsteren   +23 more
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance [PDF]

, 2007
This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance.
Carpenter, Gail A., Woods, Matthew
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Complete Genome Sequence Analysis of a Dengue Case Co-Infected with Type I and Type II Imported into Jiaxing in 2023

Microbiology Research
In 2023, one case of coinfection with type I and type II dengue virus of imported origin was first reported in Jiaxing city. Therefore, we analysed the results of the molecular tracing analysis of this case.
Yamei Zhou, Shencong Lv, Hao Yan, Ganglin Ren, Yin Song, Jimei Jj, Lina Li, Yong Yan, Guoying Zhu   +8 more
doaj   +1 more source

Completion of the amino acid sequence of papain [PDF]

Biochemical Journal, 1969
Papain was inhibited with bromo[2−14C]acetic acid, the tertiary structure of the inhibited enzyme was unfolded and the disulphide bridges were reduced with mercaptoethanol and aminoethylated. Digestion with trypsin gave a radioactive peptide consisting of residues 18–58 inclusive and containing therefore the sequence of the thirteen unknown residues 29–
G. Lowe, S. S. Husain
openaire   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Value of eight-amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigation

Clinical and Molecular Allergy, 2009
The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit allergic reactions.
ThirumalaiswamySekhar Arvind, Song Ping, Herman Rod A   +2 more
doaj   +1 more source

Purification and Characterization of a 44-kDa Recombinant Collagen I α 1 Fragment from Corn Grain [PDF]

, 2009
This paper demonstrates that a fibrous, repetitive amino acid sequence collagen-related protein, a 44-kDa fragment of human collagen I α 1 (CIα1), was expressed in corn grain molecularly equivalent to that produced in recombinant yeast.
Baez, Julio, Glatz, Charles, Glatz, Charles, Zhang, Cheng   +3 more
core   +3 more sources

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source