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Intestinal transport of certain N-substituted amino acids
American Journal of Physiology-Legacy Content, 1962Sarcosine, N,N-dimethylglycine and betaine were transported against concentration gradients by everted sacs of hamster small intestine. These compounds shared a common transport system which differed from that which acted on most neutral l-amino acids. The N-methyl derivatives of glycine, while competing with each other, had no effect on the transport
H, HAGIHIRA, T H, WILSON, E C, LIN
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Enzymatic resolution of Cα-fluoroalkyl substituted amino acids
Tetrahedron: Asymmetry, 2004Abstract A methodology for the enzymatic resolution of sterically constrained Cα-fluoroalkyl substituted amino acids has been developed. Racemic H-(αTfm)Ala-NH2, H-(αCF2Cl)Ala-NH2 and H-(αCF2Br)Ala-NH2 was separated with very high enantioselectivity (E >200) into their enantiomers using amidase from Mycobacterium neoaurum, yielding the corresponding (
Koksch, B. +5 more
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Postreassortment Amino Acid Substitutions in Influenza a Viruses
Future Microbiology, 2010The genome of the influenza A virus consists of eight single-stranded negative sense RNA segments. Segmentation allows reassortment of genes between influenza A virus strains when two strains infect one host cell. Reassortment may lead to the emergence of pandemic influenza viruses.
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Amino acid substitutions determining G3m(g5).
Experimental and clinical immunogenetics, 1990Amino acid substitutions specific for allotypic G3m(g5) marker were studied by sequence analysis of the C-terminal BrCN peptides of myeloma protein Ba [G3m(g5+)] and Bu [G3m(g5-)]. The results indicate that arginine and tyrosine at position 435 and 436 are responsible for the specificity.
S, Ito +3 more
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Nontransport of certain substituted amino acids
Biochemical Pharmacology, 1964R P, SPENCER, K R, BRODY, B M, LUTTERS
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Improving Amino-Acid Substitution Modelling
2007Amino-acid replacement models form an essential basis of protein phylogenetics. They are used to compute the substitution probabilities along the branches of phylogenies, and thus the likelihood of the data. They are also essential in protein alignment.
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