Results 41 to 50 of about 540,331 (291)
BMC Bioinformatics, 2006 Background Quantitative descriptions of amino acid similarity, expressed as probabilistic models of evolutionary interchangeability, are central to many mainstream bioinformatic procedures such as sequence alignment, homology searching, and protein ...
desJardins Marie +2 more
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Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis. [PDF]
PLoS Genetics, 2016 The rate at which genomes adapt to environmental changes and the prevalence of adaptive processes in molecular evolution are two controversial issues in current evolutionary genetics.
Nicolas Galtier
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The compositional adjustment of amino acid substitution matrices [PDF]
Proceedings of the National Academy of Sciences, 2003 Amino acid substitution matrices are central to protein-comparison methods. In most commonly used matrices, the substitution scores take a log-odds form, involving the ratio of “target” to “background” frequencies derived from large, carefully curated sets of protein alignments.
Yi-Kuo, Yu +2 more
openaire +2 more sources
Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation [PDF]
, 2006 APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G!92A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known.
Pace, C. +6 more
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Clinical genetic testing in four highly suspected pediatric restrictive cardiomyopathy cases
BMC Cardiovascular Disorders, 2022 Background Restrictive cardiomyopathy (RCM) presents a high risk for sudden cardiac death in pediatric patients. Constrictive pericarditis (CP) exhibits a similar clinical presentation to RCM and requires differential diagnosis.
Min Zheng +5 more
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Biomolecules, 2021 Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using ...
Areetha R. D’Souza +4 more
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Trends in Substitution Models of Molecular Evolution
Frontiers in Genetics, 2015 Substitution models of evolution describe the process of genetic variation through fixed mutations and constitute the basis of the evolutionary analysis at the molecular level. Almost forty years after the development of first substitution models, highly
Miguel eArenas
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To screen the human-mouse chimeric antibodies that neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyse the key amino acid site changes in their light chain.Methods·Antibody heavy chain gene-humanized mice ...
YIN Zi +5 more
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Tracing Hybrid Incompatibilities to Single Amino Acid Substitutions [PDF]
Molecular Biology and Evolution, 2005 Deleterious interactions among genes cause reductions in fitness of interpopulation hybrids (hybrid breakdown). Identifying genes involved in hybrid breakdown has proven difficult, and few studies have addressed the molecular basis of this widespread phenomenon.
J Scott, Harrison, Ronald S, Burton
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Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance [PDF]
, 2012 Trypanosoma brucei rhodesiense (Tbr) and T. b. gambiense (Tbg), causative agents of Human African Trypanosomiasis (sleeping sickness) in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs), components
A MacLeod +31 more
core +3 more sources