Results 31 to 40 of about 540,331 (291)

Estimating selection pressures on HIV-1 using phylogenetic likelihood models [PDF]

, 2008
Human immunodeficiency virus (HIV-1) can rapidly evolve due to selection pressures exerted by HIV-specific immune responses, antiviral agents, and to allow the virus to establish infection in different compartments in the body. Statistical models applied
Anisimova, Bailey, Embretson, Felsenstein, Goldman, Guindon, Ho, Huelsenbeck, Huelsenbeck, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Mansky, Massingham, Mayer-Hamblett, Muse, Nielsen, Novitsky, Pantaleo, Perelson, Perelson, Poon, Richman, Robinson, Rodrigue, Saitou, Schadt, Scheffler, Self, Seoighe, Shriner, Smith, Sugiura, Suzuki, Wei, Whelan, Whitley, Williamson, Yang, Yang, Yang, Yang, Yang, Zhuang   +47 more
core   +1 more source

Trans-Bilayer Ion Conduction by Proline Containing Cyclic Hexapeptides and Effects of Amino Acid Substitutions on Ion Conducting Properties [PDF]

, 2010
Several ion channel forming cyclic peptides have been reported over the past two decades and various ion conducting mechanisms have been proposed. In this article, we report on amino acid substitutions in cyclic hexapeptides and their effects on the ion ...
Aoyagi, Haruhiko, Hayashi, Ryo, Jelokhani-Niaraki, Masoud, Kodama, Hiroaki, Osada, Saoshi, Taira, Junichi, Ueda, Toshihisa   +6 more
core   +2 more sources

Structural topological analysis of spike proteins of SARS-CoV-2 variants of concern highlight distinctive amino acid substitution patterns

European Journal of Cell Biology, 2022
Since the onset of pandemic in 2019, SARS-CoV-2 has diverged into numerous variants driven by antigenic and infectivity-oriented selection. Some variants have accumulated fitness-enhancing mutations, evaded immunity and spread despite global vaccination ...
Filips Peisahovics, Mohammed A. Rohaim, Muhammad Munir   +2 more
doaj   +1 more source

Nonadaptive Amino Acid Convergence Rates Decrease over Time. [PDF]

, 2015
Convergence is a central concept in evolutionary studies because it provides strong evidence for adaptation. It also provides information about the nature of the fitness landscape and the repeatability of evolution, and can mislead phylogenetic inference.
Goldstein, RA, Pollard, ST, Pollock, DD, Shah, SD   +3 more
core   +1 more source

Back-translation for discovering distant protein homologies [PDF]

, 2009
Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin.
A. Pedersen, B. Oostra, C. Kosiol, J. Leluk, J. Leluk, J. Raes, K. Okamura, L. Arvestad, L. Delaye, M. Clamp, M. Pellegrini, P. Harrison, P. Lio, R. Blake, S. Altschul, S. Altschul, S. Altschul, Y. Hahn   +17 more
core   +10 more sources

Different Accumulation of Free Amino Acids during Short- and Long-Term Osmotic Stress in Wheat

The Scientific World Journal, 2012
The effect of wheat chromosome 5A on free amino acid accumulation induced by osmotic stress was compared in chromosome 5A substitution lines with different freezing tolerance.
Zita Kovács, Livia Simon-Sarkadi, Ildikó Vashegyi, Gábor Kocsy   +3 more
doaj   +1 more source

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

Scientific Reports, 2023
The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage.
Ulrich Bornschein, Hugo Zeberg, Wolfgang Enard, Wulf Hevers, Svante Pääbo   +4 more
doaj   +1 more source

A Hierarchical Approach to Protein Molecular Evolution [PDF]

, 1999
Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo ...
Crameri, Cwirla, Davidson, Devlin, Fisch, Gilbert, Gilbert, Gram, Griffiths, Hawkins, Kamtekar, Kauffman, Kauffman, Kepler, L. D. Bogarad, Lawrence, M. W. Deem, Maeshiro, Mandecki, Moore, Netzer, Patten, Pennisi, Perelson, Riddle, Scott, Shapiro, Shapiro, Stemmer, Stemmer, Zhang   +30 more
core   +2 more sources

FLU, an amino acid substitution model for influenza proteins

BMC Evolutionary Biology, 2010
Background The amino acid substitution model is the core component of many protein analysis systems such as sequence similarity search, sequence alignment, and phylogenetic inference.
Gascuel Olivier, Le Quang, Dang Cuong, Le Vinh   +3 more
doaj   +1 more source

Insight into mosquito GnRH-related neuropeptide receptor specificity revealed through analysis of naturally occurring and synthetic analogs of this neuropeptide family [PDF]

, 2019
Adipokinetic hormone (AKH), corazonin (CRZ), and the AKH/CRZ-related peptide (ACP) are neuropeptides considered homologous to the vertebrate gonadotropin-releasing hormone (GnRH).
Gade, Gerd, Paluzzi, Jean-Paul, Wahedi, Azizia   +2 more
core   +1 more source