Results 11 to 20 of about 540,331 (291)
Amino-acid Substitution in Haemoglobin I (Texas Variant) [PDF]
Nature, 1967 AN electrophoretically fast genetic variant of adult haemoglobin was described in six members of a Negro family living in Texas by Thompson et al. in 1963 (ref. 1). Fingerprints of the purified haemoglobin established the identity of this variant with haemoglobin I previously described by Murayama and Ingram2, in which the third tryptic peptide from ...
B H, Bowman, D R, Barnett
openaire +4 more sources
Predicting Deleterious Amino Acid Substitutions [PDF]
Genome Research, 2001 Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology to predict whether a substitution affects protein function.
P C, Ng, S, Henikoff
openaire +2 more sources
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
Nature Communications, 2022 The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation.
Sabine M. Ulamec +11 more
doaj +1 more source
Next-generation development and application of codon model in evolution
Frontiers in Genetics, 2023 To date, numerous nucleotide, amino acid, and codon substitution models have been developed to estimate the evolutionary history of any sequence/organism in a more comprehensive way.
Manoj Kumar Gupta, Ramakrishna Vadde
doaj +1 more source
Combinatorial codon-based amino acid substitutions [PDF]
Nucleic Acids Research, 2004 Twenty Fmoc-protected trinucleotide phosphoramidites representing a complete set of codons for the natural amino acids were chemically synthesized for the first time. A pool of these reagents was incorporated into oligonucleotides at substoichiometric levels to generate two libraries of variants that randomly carry either few or many codon replacements
Jorge, Yáñez +4 more
openaire +2 more sources
Selective constraints on amino acids estimated by a mechanistic codon substitution model with multiple nucleotide changes. [PDF]
PLoS ONE, 2011 BACKGROUND: Empirical substitution matrices represent the average tendencies of substitutions over various protein families by sacrificing gene-level resolution. We develop a codon-based model, in which mutational tendencies of codon, a genetic code, and
Sanzo Miyazawa
doaj +1 more source
BMC Evolutionary Biology, 2020 Background Amino acid substitution models play an important role in inferring phylogenies from proteins. Although different amino acid substitution models have been proposed, only a few were estimated from mitochondrial protein sequences for specific ...
Huihui Chang +7 more
doaj +1 more source
Patterns of Protein Evolution in Cytochrome c Oxidase 1 (COI) from the Class Arachnida. [PDF]
PLoS ONE, 2015 Because sequence information is now available for the 648bp barcode region of cytochrome c oxidase 1 (COI) from more than 400,000 animal species, this gene segment can be used to probe patterns of mitochondrial evolution.
Monica R Young, Paul D N Hebert
doaj +1 more source
BMC Bioinformatics, 2010 Background Sequence comparisons make use of a one-letter representation for amino acids, the necessary quantitative information being supplied by the substitution matrices.
Zimmermann Karel, Gibrat Jean-François
doaj +1 more source
Veterinary Integrative Sciences, 2022 Porcine parvovirus 1 (PPV1) is the causative agent of swine reproductive disease, particularly in naive gilts and sows. This study aimed to investigate the prevalence and genetic diversity of the partial nucleotide sequence of the VP2 gene and ...
Prayuth Saekhow +2 more
doaj +1 more source