Results 21 to 30 of about 34,511,928 (256)

SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer

Cancer Cell International, 2021
Background SLC7A7 (solute carrier family 7, amino acid transporter light chain, y + L system, member 7) is a critical gene in the regulation of cationic amino acid transport.
Wumin Dai, Jianguo Feng, Xiao Hu, Yongyi Chen, Qing Gu, Wangang Gong, Tingting Feng, Jie Wu   +7 more
doaj   +1 more source

Transport of Amino Acids Across the Blood-Brain Barrier

Frontiers in Physiology, 2020
The blood-brain-barrier (BBB), present in brain capillaries, constitutes an essential barrier mechanism for normal functioning and development of the brain.
Rosa Zaragozá
doaj   +1 more source

System y+L: the broad scope and cation modulated amino acid transporter

Experimental Physiology, 1998
The properties are discussed of system y+L, a broad scope amino acid transporter which was first identified in human erythrocytes. System y+L exhibits two distinctive properties: (a) it can bind and translocate cationic and neutral amino acids, and (b) its specificity varies depending on the ionic composition of the medium.
R, Devés, S, Angelo, A M, Rojas
openaire   +2 more sources

The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signalling in mouse skeletal muscle [PDF]

, 2014
The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and cell ...
Adel F M Ibrahim, Yun-Bo Shi, Mitchell, Fiona E., Grant English (527945), Peter M Taylor, Taylor Peter M., Poncet, Nadège, Fiona E Mitchell, Ibrahim Adel F. M., English, Grant, J. Simon C Arthur (527946), Nadège Poncet, Victoria A McGuire, Yun-Bo Shi (193634), Arthur J. Simon C, McGuire Victoria A., Adel F. M. Ibrahim (188343), Grant English, Taylor, Peter M., Ibrahim, Adel F. M., Poncet Nadège, Nadège Poncet (527942), Victoria A. McGuire (527944), Peter M. Taylor (527947), McGuire, Victoria A., English Grant, Arthur, J. Simon C; id_orcid, Mitchell Fiona E., Shi Yun-Bo, Fiona E. Mitchell (527943), Shi, Yun-Bo, J Simon C Arthur   +31 more
core   +1 more source

The amino acid transport system y ⁺ L/4F2hc is a heteromultimeric complex

The FASEB Journal, 1998
4F2hc is an almost ubiquitous transmembrane protein in mammalian cells; upon expression in Xenopus laevis oocytes, it induces amino acid transport with characteristics of system y + L.
Estévez, Raúl, Camps, Marta, Rojas, Ana María, Testar, Xavier, Devés, Rosa, Hediger, Matthias A., Zorzano, Antonio, Palacín, Manuel   +7 more
openaire   +2 more sources

Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3 [PDF]

, 2004
Amino acids are regarded as the nitrogen ‘currency’ of plants. Amino acids can be taken up from the soil directly or synthesized from inorganic nitrogen, and then circulated in the plant via phloem and xylem.
Sakiko Okumoto, Leister, D., Frommer, Wolf B., Wolf B. Frommer, Okumoto, Sakiko, FISCHER, Wolf N, Stierhof, York Dieter, Frommer, W. B., Stierhof, Y., Stierhof, Y.-D., Fischer, W., Wolfgang Koch, Koch, W., FROMMER, Wolf B, Mechthild Tegeder, Fischer, Wolf N., Leister, Dario, Wolf N. Fischer, Koch, Wolfgang, Okumoto, S., Tegeder, Mechthild, Dario Leister, Tegeder, M., Biehl, A., York Dieter Stierhof, Alexander Biehl, Biehl, Alexander, Fischer, W. N., Frommer, W.   +28 more
core   +2 more sources

Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Y+LAT1 protein, encoded by the SLC7A7 gene (a member of the SLC7 family), forms the cationic amino acid transport system y+L (system y+L). This system transports cationic amino acids such as arginine and lysine out of the cell. Arginine,
Xiaohui Ji, Xiaoyun Yang, Nan Wang, Meiyun Kang, Yaping Wang, Liucheng Rong, Yongjun Fang, Yao Xue   +7 more
doaj   +1 more source

The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis [PDF]

, 2013
The beet cyst nematode Heterodera schachtii is able to infect Arabidopsis plants and induce feeding sites in the root. These syncytia are the only source of nutrients for the nematodes throughout their life and are a nutrient sink for the host plant.
Elashry, Abdelnaser, Siddique, Shahid, Koch, Wolfgang, Kreil, David, Okumoto, Sakiko, Bohlmann, Holger, Kreil, David P.   +6 more
core   +1 more source

Analysis of LPI-causing mutations on y+LAT1 function and localization

Orphanet Journal of Rare Diseases, 2019
Background y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal
Bianca Maria Rotoli, Amelia Barilli, Filippo Ingoglia, Rossana Visigalli, Massimiliano G. Bianchi, Francesca Ferrari, Diego Martinelli, Carlo Dionisi-Vici, Valeria Dall’Asta   +8 more
doaj   +1 more source

Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. [PDF]

Proceedings of the National Academy of Sciences, 1992
A kidney cortex cDNA clone (rBAT) has recently been isolated, which upon in vitro transcription and capping complementary RNA (cRNA) and injection into Xenopus laevis oocytes induces a system b0,(+)-like amino acid transport activity. This cDNA encodes a type II membrane glycoprotein that shows significant homology to another type II membrane ...
Bertran, J, Magagnin, S, Werner, A, Markovich, D, Biber, J, Testar, X, Zorzano, A, Kuhn, LC, Palacin, M, Murer, H   +9 more
openaire   +6 more sources