AbstractOver 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and
Elizabeth L. Lieu+3 more
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Amino Acids and Inherited Amino Acid-Related Disorders [PDF]
Amino acids perform multiple essential physiological roles in humans, and accordingly, their importance to health has been the subject of extensive attention. In this special issue of the Journal of Nutrition and Metabolism, we focus on the various inborn errors of amino acid metabolism, their diagnostic challenges, new treatment approaches, and recent
Ina Knerr+5 more
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Photosynthesis of amino acids [PDF]
Abstract Methods have been developed for performing dual tracer experiments with 15 N and 14 C on the photosynthesis and biosynthesis of amino acids in Chlorella pyrenoidosa . These methods involved the development of apparatus for maintaining algae in a condition of steady-state photosynthesis, including amino acid synthesis, and of adding ...
Bassham, J.A., Kirk, Martha.
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Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids [PDF]
A Lewis-acid promoted one-carbon homologation of an aspartic acid semialdehyde with trimethylsilyldiazomethane has led to the efficient synthesis of two silicon-containing α-amino acids.
Adamczyk+70 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Mark G. Moloney+2 more
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Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization [PDF]
A human liver cDNA library was used to isolate a clone coding for apolipoprotein A-I (Apo A-I). The clone carries the sequence for the prepeptide (18 amino acids), the propeptide (6 amino acids), and the mature protein (243 amino acids).
Bollen, A.+12 more
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Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Hammer, C.+7 more
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Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord [PDF]
Double-barrelled pH-sensitive micro-electrodes were used to measure changes of intracellular and extracellular pH in and around motoneurons of the isolated frog spinal cord during application of excitatory amino acids.
Ammann+20 more
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Enantiomerically pure β-phenylalanine analogues from α–β-phenylalanine mixtures in a single reactive extraction step [PDF]
An efficient and selective method for the extraction of α-amino acids in preference over their β-isomers using PdCl2(PPh3)2 was discovered, which enables the separation of product mixtures obtained in the enantioselective enzymatic formation of β-amino ...
Feringa, Ben L.,+6 more
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Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis [PDF]
Indexación: ScieloWe report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%.
Fernández, Jorge+9 more
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