Results 201 to 210 of about 148,306 (298)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Amino acid metabolism modulates macrophage polarization: implications for autoimmune-related diseases. [PDF]

Front Immunol
Yin Y, Yan C, Pei X, Rao J, Wu L, Xue Y, Sun H, Sheng Y.   +7 more
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Metabolites in Early-Mid Pregnancy Mediate the Association Between Prepregnancy Body Mass Index and Risk of Gestational Diabetes Mellitus. [PDF]

J Diabetes Res
Wang S, Zheng Y, Luo M, Chen W, Guo J, Jiang R, Yu X.   +6 more
europepmc   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Aroma metabolism during the low-temperature storage of Hami melons: volatile odor-active compounds, precursors, and enzyme activity. [PDF]

Front Nutr
Hao X, Peng B, Shan C, Liao W, Yang M, Ning M, Zhang Q, Tang F.   +7 more
europepmc   +1 more source

Janus‐Type Electrostatic Potential Gradient‐Activated Dynamic Zn2+‐Coordinating Nitrogen Sites in Molecularly Locked Nanocellulose Separators for Stable Zinc‐Ion Batteries

Advanced Science, EarlyView.
A multifunctional benzimidazole‐terminated CNF separator is constructed via a PEI‐mediated covalent locking strategy, generating dense zincophilic sites that accelerate Zn2+ transport and desolvation while enabling uniform Zn (002) deposition and suppressing side reactions.
Jie Liang, Shuxin Yang, Shuaiqi Zhao, Haitao Yang, Jingyuan Li, Jiaming Dong, Junwen Duan, Hao Yang, Yue Li, Yaxin Wang, Meilin Li, Ying Liu, Zhitao Shen, Rong Liu, Ruirui Cao, Fumin Li, Minshen Zhu, Yang Huang   +17 more
wiley   +1 more source

Association and predictive value of blood branched-chain and excitatory amino acids with autism spectrum disorder severity. [PDF]

BMC Pediatr
Li J, Wang Y, Bi L, Yang X, Yang Y, Zhang Q, Mei X, Dang W, Feng G, Zhang X, Zhou R.   +10 more
europepmc   +1 more source

Synthesis of Novel Stable ZnSe Magic‐Sized Clusters and Their Direct Transformation to Quantum Dots

Advanced Science, EarlyView.
We have developed a low‐temperature synthetic approach that enables the fabrication of novel ZnSe MSCs with remarkable thermal stability. These stabilized MSCs serve as efficient precursors that can be readily converted to ZnSe QDs under mild conditions through simple introduction of a selenium source.
Bin Song, Zihui Jin, Xuanyu Zhang, Rong‐Jun Xie   +3 more
wiley   +1 more source

GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis. [PDF]

Circulation
Wang H, Wang J, Zhu M, Jin L, Cui H, Liu C, Fan C, Li H, Yang J, Cui M, Song J, Wang W, Xu M.   +12 more
europepmc   +1 more source