Results 221 to 230 of about 92,957 (299)

Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications. [PDF]

BMC Med
Cai Y, Jin J, Wang Y, Han D, Yu X, Jin F, Li M, Li Y, Li X.   +8 more
europepmc   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Hypertension incidence according to branched-chain amino acid intake in Brazilian adults: a six-year follow-up of the CUME study. [PDF]

Eur J Nutr
da Silva FMO, Pimenta AM, Juvanhol LL, Hermsdorff HHM, Bressan J.   +4 more
europepmc   +1 more source

Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1 activity for prognosis and tailored therapy in ccRCC. [PDF]

Front Cell Dev Biol
Weng KQ, Li X, Chen XB, Lin JW, Liu LJ, Yan LY, Xie RY.   +6 more
europepmc   +1 more source

Independent Evolution of Linear and Branched Cuticular Hydrocarbons in Ants: A Hypothesis. [PDF]

Insects
Hefetz A.
europepmc   +1 more source

Amino Acid Imbalance Is an Independent Factor for Mortality in Patients With Liver Cirrhosis. [PDF]

Aliment Pharmacol Ther
Utakata Y, Miwa T, Unome S, Masuda N, Oi M, Aiba M, Imai K, Takai K, Shiraki M, Katsumura N, Shimizu M.   +10 more
europepmc   +1 more source

Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia. [PDF]

Mol Nutr Food Res
Parfenova EN, Spagnuolo PA.
europepmc   +1 more source

Amino Acid Metabolism in Chronic Liver Disease: from Pathogenic Driver to Therapeutic Target. [PDF]

Int J Biol Sci
Huang Y, Jiang Y, Ye W, Hu X, Abudurexiti N, Li J, Li C, Chen R, Xu X.   +8 more
europepmc   +1 more source

Porcine gut loops to explore the impact of amino acids on the host-microbiota crosstalk in the ileum. [PDF]

Front Microbiol
Renois F, Hervet C, Barc C, Kasal-Hoc N, Jones E, Roux C, Gagnon D, Chalvon-Demersay T, Beaumont M, Meurens F.   +9 more
europepmc   +1 more source

Study on the Molecular Mechanism of Interaction Between Perfluoroalkyl Acids and PPAR by Molecular Docking. [PDF]

Toxics
Wei R, Xiao H, Fu J, Luo Y, Wang P.
europepmc   +1 more source