Results 1 to 10 of about 8,648 (155)

Modular assembly of chiral amino acid derivatives and peptides from commonly available feedstocks [PDF]

Nature Communications
α-Amino acids are fundamental components of proteins and natural molecules, with non-natural variants highly valued in both academia and industry for their ability to tune chemical, physical, and pharmaceutical properties.
Wei-Wei Ding, Zhi-Yuan He, Wan-Yu Wang, Zhi-Yong Han, Liu-Zhu Gong   +4 more
doaj   +2 more sources

Structural and functional insights into δ-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii

Communications Biology, 2023
Cationic homo-polyamino acid (CHPA) peptides containing isopeptide bonds of diamino acids have been identified from Actinomycetes strains. However, none has been reported from other bacteria.
Ketan D. Patel, Andrew M. Gulick
doaj   +1 more source

Peptide Dendrimers: From Enzyme Models to Antimicrobials and Transfection Reagents

CHIMIA, 2021
Aiming at studying cooperativity effects between amino acids in easily accessible protein models, we have explored the chemistry of peptide dendrimers, which we obtain as pure products by solid-phase peptide synthesis using a branching diamino acid such ...
Jean-Louis Reymond
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1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Helical versus Flat Bis-Ferrocenyl End-Capped Peptides: The Influence of the Molecular Skeleton on Redox Properties

Molecules, 2022
Despite the fact that peptide conjugates with a pendant ferrocenyl (Fc) have been widely investigated, bis-ferrocenyl end-capped peptides are rarely synthetized.
Saverio Santi, Barbara Biondi, Roberta Cardena, Annalisa Bisello, Renato Schiesari, Silvia Tomelleri, Marco Crisma, Fernando Formaggio   +7 more
doaj   +1 more source

In silico and in vivo screening of triamterene synthetic analogues as promising diuretics

Medičnì Perspektivi, 2022
The modification of lead-compound aimed to the increasing of activity, decrement of toxicity or improvement of selectivity is one of the most important methods used for elaboration of novel medications.
K.V. Sokolova, V.V. Stavytskyi , O.Yu. Voskoboinik , O.A. Podpletnya , S.I. Kovalenko   +4 more
doaj   +1 more source

The Stereoselective Nitro-Mannich Reaction in the Synthesis of Active Pharmaceutical Ingredients and Other Biologically Active Compounds

Frontiers in Chemistry, 2020
The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective
Ana Maria Faisca Phillips, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro   +2 more
doaj   +1 more source

Application of Nickel(II) Complexes to the Efficient Synthesis of ?- or ?-Amino Acids

CHIMIA, 2011
Nonproteinogenic ?- or ?-amino acids have attracted tremendous attention, as they are widely utilized for biological, biochemical, pharmaceutical, and asymmetric chemical investigations.
Jiang Wang, Lei Zhang, Hualiang Jiang, Kaixian Chen, Hong Liu   +4 more
doaj   +1 more source

Co-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars

Scientific Reports, 2022
Aromatic rice (Oryza sativa) fetches a premium price due to the pleasant aroma. The major aroma compound 2-acetyl-1-pyrroline (2AP) has been found to be enhanced under stress.
N. Renuka, Vitthal T. Barvkar, Zahid Ansari, Chunfang Zhao, Cailin Wang, Yadong Zhang, Altafhusain B. Nadaf   +6 more
doaj   +1 more source

Lysinuric protein intolerance in a 5-month-old girl

Medical Journal of Dr. D.Y. Patil University, 2016
Lysinuric protein intolerance (LPI), also known as cationic aminoaciduria, hyperdibasic aminoaciduria type 2, or familial protein intolerance, is an autosomal recessive defect of diamino acid transport.
Viplav Narayan Deogaonkar, Ira Shah
doaj   +1 more source