Results 91 to 100 of about 2,014,878 (300)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effect of Processing Methods on Amino Acid and Fatty Acid Composition of Parkia biglobosa Seeds

Applied Sciences
Parkia biglobosa (PB) is among the various underexploited nutritious plants. A comparative study was conducted on the effect processing PB has on the amino and fatty acid composition.
Foluso Oluwagbemiga Osunsanmi, Bolajoko Idiat Ogunyinka, Babatunji Emmanuel Oyinloye, Andrew Rowland Opoku, Abidemi Paul Kappo   +4 more
doaj   +1 more source

Apparent total tract digestibility and ileal digestibility of dry matter, nitrogen, energy and amino acids in conventional, Bacillus subtilis-fermented and enzyme-treated soybean meal fed to weanling pigs

Veterinární Medicína, 2016
Apparent total tract digestibility (ATTD), apparent ileal digestibility (AID) and standardised ileal digestibility (SID) of dry matter, nitrogen, energy and amino acids were evaluated in six weanling barrows [(Landrace × Yorkshire) × Duroc] fed soybean ...
M.M. Hossain, M. Begum, J.H. Park, S.J. Lee, K.H. Jang, Y.H. Hong, S.J. Cho, I.H. Kim   +7 more
doaj   +1 more source

The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression. [PDF]

Int J Mol Sci, 2021
Conseil G, Cole SPC.
europepmc   +1 more source

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Cell, 2010
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting
Y. Sancak, L. Bar-Peled, R. Zoncu, Andrew L. Markhard, S. Nada, D. Sabatini   +5 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Application of Alanine Scanning to Determination of Amino Acids Essential for Peptide Adsorption at the Solid/Solution Interface and Binding to the Receptor: Surface-Enhanced Raman/Infrared Spectroscopy versus Bioactivity Assays. [PDF]

J Med Chem, 2021
Proniewicz E, Burnat G, Domin H, Małuch I, Makowska M, Prahl A.   +5 more
europepmc   +1 more source

Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation

BioMed Research International, 2018
Intestine is always exposed to external environment and intestinal microorganism; thus it is more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and ...
Fang He, Chenlu Wu, Pan Li, Nengzhang Li, Dong Zhang, Quoqiang Zhu, W. Ren, Yuanyi Peng   +7 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source