Results 91 to 100 of about 6,089,688 (338)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Essential Amino Acids for Muscle Protein Accretion

, 2010
SUMMARY: THE STIMULATION OF MUSCLE PROTEIN SYNTHESIS IS RELIANT ON THE ADEQUATE AVAILABILITY OF AMINO ACID (AA) PRECURSORS. THE INCREASE IN CIRCULATING AA CONCENTRATIONS IN THE BLOOD SERVES AS A SIGNAL TO INITIATE SYNTHETIC PROCESSES.
Wolfe, RR, Ferrando, Arny A, Ferrando, AA, Tipton, Kevin, Wolfe, Robert R   +4 more
core   +1 more source

Regulatory effects of blood constituents on the function and metabolism of the cat brain in perfusion ezperiments. Brain perfusion with artificial blood containing low molecular dextran and amino acids [PDF]

, 1967
As a link in a series of studies on the effects of blood constituents on the brain function by means of brain perfusion, we used four kinds of artificial blood; namely, the blood containing a low molecular dextran, one containing glutamic acid, one ...
Nakashima, Yoshihiko, Watanabe, Shosuke, Okumura, Nikichi, Edamatsu, Kazuyasu, Otsuki, Saburo, Morimitsu, Junsuke   +5 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population

Metabolites, 2019
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population.
Yonghai Lu, Yeli Wang, Xu Liang, Li Zou, Choon Nam Ong, Jian-Min Yuan, Woon-Puay Koh, An Pan   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Species Variations in the Proximate Composition, Amino Acid Profile, and Protein Quality of the Muscle Tissue of Grass Carp, Bighead Carp, Siberian Sturgeon, and Wels Catfish

Journal of Food Quality, 2018
This study determined the proximate composition, energy value, amino acid profile, and protein quality of the muscle tissue of four food fish species. The fish analyzed contained 78.90–69.89% water, 18.25–15.69% protein, and 2.28–12.57% fat.
Renata Pyz-Łukasik, Waldemar Paszkiewicz   +1 more
doaj   +1 more source

AMINO ACID AND FATTY ACID PROFILES IN LOCAL TIGRIS CATFISH (SILURUS TRIOSTEGUS) MEAT [PDF]

Assiut Veterinary Medical Journal
This study aimed to determine the pattern, composition, and ratios of fatty and amino acids in the meat of the local Tigris catfish (Silurus triostegus) to estimate its nutritional value.
MAZIN AL-ZUBAIDY, SURA AL-TAK
doaj   +1 more source

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

Nutrition and Metabolism, 2018
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years.
M. Holeček
semanticscholar   +1 more source