Results 11 to 20 of about 7,755,658 (385)

Metabolism of Amino Acids in Cancer

Frontiers in Cell and Developmental Biology, 2021
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids.
Zhen Wei, Xiaoyi Liu, Chunming Cheng, Wei Yu, P. Yi   +4 more
semanticscholar   +1 more source

Amino acids in cancer

Experimental and Molecular Medicine, 2020
Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1.
Elizabeth L. Lieu, Tu-Lan Nguyen, Shawn Rhyne, Jiyeon Kim   +3 more
semanticscholar   +1 more source

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics*

Molecular & Cellular Proteomics, 2002
Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification and ...
Shao-En Ong, B. Blagoev, I. Kratchmarova, D. B. Kristensen, H. Steen, A. Pandey, M. Mann   +6 more
semanticscholar   +1 more source

Branched Chain Amino Acids.

Annual Review of Physiology, 2019
Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology.
Michael D. Neinast, Danielle S Murashige, Z. Arany   +2 more
semanticscholar   +1 more source

Branched Chain Amino Acids: Beyond Nutrition Metabolism

International Journal of Molecular Sciences, 2018
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals.
C. Nie, Ting He, Wenju Zhang, Guolong Zhang, Xi Ma   +4 more
semanticscholar   +1 more source

Branched-chain amino acids in disease

Science, 2019
Are BCAAs a biomarker, causal agent, or both in cardiometabolic disease? Human proteins are assembled from 20 amino acids, nine of which are considered “essential” because they cannot be synthesized from other metabolites in the human body.
P. White, C. Newgard
semanticscholar   +1 more source

Alterations in serum amino acid concentrations in dogs with protein-losing enteropathy [PDF]

, 2018
BackgroundCertain amino acids are decreased in humans with inflammatory bowel disease (IBD) and supplementation with the same amino acids has shown beneficial effects in animal models of IBD.
Allenspach, Beeken, Bettenworth, Clayton, Coburn, Dąbrowski, Gupta, Hashimoto, Hou, Kim, Kim, Li, Liu, Liu, Middleton, Morgan, Nikolaus, Ren, Richard, Ruth, Schrocksnadel, Tsune, Walser, Wang, Widner, Xin   +25 more
core   +4 more sources

Excitatory Amino Acids.

ChemInform, 1998
AbstractFor Abstract see ChemInform Abstract in Full Text.
Mark G. Moloney, Mark G. Moloney, Mark G. Moloney   +2 more
openaire   +5 more sources

A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code

, 2009
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
Chakrabarti S., Paul G. Higgs, Ralph E. Pudritz   +2 more
core   +1 more source

Distances and classification of amino acids for different protein secondary structures

, 2003
Window profiles of amino acids in protein sequences are taken as a description of the amino acid environment. The relative entropy or Kullback-Leibler distance derived from profiles is used as a measure of dissimilarity for comparison of amino acids and ...
J. Garnier, Li-mei Zhang, O. Weiss, O. Weiss, P. Stolorz, S. Henikoff, Shan Guan, U. Hobohm, W. Kabsch, Wei-Mou Zheng, Xin Liu   +10 more
core   +2 more sources