Results 21 to 30 of about 1,395,787 (296)

Amino acid neurotransmitters in the CNS

FEBS Letters, 1986
D‐Aspartate exchange, defined as amino acid‐stimulated D‐[3H]aspartate efflux, was investigated in a preparation of rat brain synaptosomes. The efflux of radiolabelled D‐aspartate was found to be enhanced by micromolar concentrations of externally added D‐ and L‐aspartate, L‐glutamate, L‐cysteate.and L‐cysteinesulphinate.
Maria Erecińska, Melody B. Troeger
openaire   +3 more sources

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D

Amino Acids
Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care.
Sandra Rodrigues Xavier, Isabelle Caroline dos Santos Barcelos, Isadora Braga Gandra, Sabrina Paula Pereira, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Lucas da Silva Lopes, Rafaela Camargo Rodrigues Machado, Leonardo Maciel Santos Silva, Líria Souza Silva, Lívia Corrêa Ferreira, Luiz Fellype Alves de Souza, Rutilene Barbosa Souza, Ana Maísa Passos-Silva, Mariana Campos da Paz, Miguel Angel Chávez Fumagalli, Eduardo Antônio Ferraz Coelho, Rodolfo Cordeiro Giunchetti, Juliana Martins Machado, Ana Alice Maia Gonçalves, Soraya dos Santos Pereira, Daniel Archimedes da Matta, Deusilene Souza Vieira, Alexsandro Sobreira Galdino   +24 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

CacyBP/SIP - RPL6 interaction: potential influence on ribosome function

Amino Acids
Previously, we have shown that CacyBP/SIP interacts with NPM1, a protein involved in ribosome biogenesis. In this work, we extended our previous studies to look for the potential impact of CacyBP/SIP on ribosome biogenesis and/or function.
Ewelina Jurewicz, Małgorzata Maksymowicz-Trivedi, Omid Saberi-Khomami, Olga Iwańska, Agata Starosta, Ewa Kilańczyk, Paweł Bieganowski, Adam Jarmuła, Wiesława Leśniak, Sławomir Filipek, Anna Filipek   +10 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Construction of a co-reaction system for ethanol-promoted gamma-aminobutyric acid synthesis by Pediococcus pentosaceus

Amino Acids
The biotransformation of L-glutamic acid (L-Glu) to γ-aminobutyric acid (GABA) using glutamate decarboxylase (GAD) in microbial whole cells represents an ideal approach for biosynthesis of food-grade and pharmaceutical-grade GABA.
Sheng-Yuan Yang, Yuan-Jun Li, Wan-Chun Hong   +2 more
doaj   +1 more source