Results 71 to 80 of about 2,349,548 (333)

Systematic qualitative proteome-wide analysis of lysine malonylation profiling in Platycodon grandiflorus

Amino Acids
In recent years, it was found that lysine malonylation modification can affect biological metabolism and play an important role in plant life activities. Platycodon grandiflorus, an economic crop and medicinal plant, had no reports on malonylation in the
Qingshan Yang, Shaowei Xu, Weimin Jiang, Fei Meng, Shuting Wang, Zongping Sun, Na Chen, Daiyin Peng, Juan Liu, Shihai Xing   +9 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Amino Acids Sequences Analysis on Collagen [PDF]

, 2007
Staring from available information about amino acids properties and sequences on collagen type I chains, the aims of the study were to identify the principal property component and to analyze the similarities within and between collagens on five species.
BOLBOACA, Dr. Sorana D., JÄNTSCHI, Dr. Lorentz   +1 more
core  

Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein

Amino Acids
In recent years, the use of cationic peptides as alternative drugs with anticancer activity has received attention. In this study, the targeted release of curcumin (Cur) and CM11 peptide alone and together against hepatocellular carcinoma (HCC) was ...
Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam   +2 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a [PDF]

, 2008
Acid-sensing ion channels are ligand-gated cation channels, gated by extracellular H+. H+ is the simplest ligand possible, and whereas for larger ligands that gate ion channels complex binding sites in the three-dimensional structure of the proteins have
Chen, Xuanmao, Grunder, Stefan, Paukert, Martin, Polleichtner, Georg, Schindelin, Hermann   +4 more
core   +1 more source

Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity

Amino Acids
Taurine, although not a coding amino acid, is the most common free amino acid in the body. Taurine has multiple and complex functions in protecting mitochondria against oxidative-nitrosative stress.
Stephanie Seneff, Anthony M. Kyriakopoulos   +1 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Amino acid analysis [PDF]

, 1974
The process and apparatus for qualitative and quantitative analysis of the amino acid content of a biological sample are presented. The sample is deposited on a cation exchange resin and then is washed with suitable solvents.
Graff, J., Winitz, M.
core   +1 more source

Metabolomic analysis reveals key changes in amino acid metabolism in colorectal cancer patients

Amino Acids
The number of colorectal cancer (CRC) patients is steadily growing worldwide, particularly in developing nations. Nonetheless, recent advances in early detection studies and therapy alternatives have reduced CRC mortality in affluent countries, despite ...
Asmaa Ramzy, Taghreed Khaled Abdelmoneim, Menna Arafat, Maha Mokhtar, Ashraf Bakkar, Amany Mokhtar, Wagida Anwar, Sameh Magdeldin, Shymaa Enany   +8 more
doaj   +1 more source