Results 31 to 40 of about 471,791 (185)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research Progress of Amino Acid Metabolism PET Imaging in Tumor

Journal of Isotopes, 2015
Amino acid metabolism PET imaging plays a very important role in metabolism molecular imaging. Amino acid PET tracers include ［1-11C］amino acid, labeling α-C amino acid, labeling side-chain amino acid, and N-substituted labeling amino acid.
NIE Da-hong, TANG Gang-hua2
doaj   +1 more source

Gut amino acid absorption in humans: Concepts and relevance for postprandial metabolism

Clinical Nutrition Open Science, 2021
Summary: Dietary amino acid absorption kinetics are an important determinant of protein quality. The term “amino acid digestibility” is commonly used to refer to the amount of ingested amino acids that become available following absorption.
Jorn Trommelen, Daniel Tomé, Luc J.C. van Loon   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comprehensive Characterization of Metabolites in Multiplier Onion Bulbs and Identification of Regulatory Genes for Nutritional Improvement

Foods
Multiplier onion (Allium cepa var. aggregatum) is an economically important Allium crop that serves dual purposes as both a culinary ingredient and medicinal resource.
Huixia Jia, Jiangping Song, Tingting Zhang, Yumin Tan, Mengzhen Wang, Jiyan Zang, Xiaohui Zhang, Wenlong Yang, Yanhui Pang, Yanfei Yang, Haiping Wang   +10 more
doaj   +1 more source

Effect of Benzothiadiazole Treatment during Veraison on Amino Acid Composition, Degradation and Metabolism in ‘Chardonnay’ Grape [PDF]

Shipin Kexue
In order to explore the effect of benzothiadiazole (BTH) treatment on amino acid accumulation, degradation and metabolism during the growth of grape fruits, ‘Chardonnay’ grape berries at veraison were sprayed with BTH at 50 mg/L and plucked once every 10
GUAN Ruwen, CHEN Chunxia, ZHANG Yu, HAN Yuqi, WANG Jianfeng, WANG Feifei, WANG Huijun, WANG Bo, JIANG Yumei
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Targeting amino acid in tumor therapy

Frontiers in Oncology
Tumor cells undergo profound metabolic reprogramming to sustain their rapid growth and proliferation, with amino acids serving as essential nutrients critical for protein synthesis, energy metabolism, nucleotide production, and redox balance.
Mingpai Ge, Yuan Xu, Lu Cui, Enyuan Huang, Zhaorui Liu, Kai Yin   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Urinary Screening for Aminoacidurias Using Chromatography and Serum Amino Acid Profile in Type 2 Diabetes and Healthy Controls

Biochemistry Research International
Type 2 diabetes is a complex metabolic disorder characterised by altered amino acid metabolism. This study investigates plasma amino acid profiles and specific aminoacidurias in patients with type 2 diabetes.
Sushma B. J., Sumit Parashar, Balvir Singh Tomar, Alka Meena, Priyanka B. J.   +4 more
doaj   +1 more source