Results 51 to 60 of about 139,294 (295)

Synthesis and Evaluation of the (S)-BINAM Derivatives as Fluorescent Enantioselective Detectors

Sensors, 2020
Pd(0)-catalyzed amination was employed for the synthesis of a new family of (S)-1,1′-bianaphthalene-2,2′-diamine derivatives possessing additional chiral and fluorophore substituents.
Alexander V. Shaferov, Anna S. Malysheva, Alexei D. Averin, Olga A. Maloshitskaya, Irina P. Beletskaya   +4 more
doaj   +1 more source

Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]

, 2016
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA, Croft, RA, Davis, OA, Doran, R, Morgan, KF   +4 more
core   +1 more source

Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols

Molecules, 2002
Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines are presented. The unsubstituted parent compound and its less hindered homologues can be obtained in high yields by tosylation ...
Maria C. F. de Araújo, Lothar W. Bieber   +1 more
doaj   +1 more source

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein [PDF]

, 2019
Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected,
Arnold, Frances H., Cho, Inha, Görbe, Tamás, Jia, Zhi-Jun, Prier, Christopher K., Zhang, Ruijie K.   +5 more
core   +1 more source

PHARMACOLOGY OF TREMOR-PRODUCING AMINO ALCOHOLS

Journal of Pharmacy and Pharmacology, 1958
Abstract The pharmacological properties of a series of amino alcohols of the general formula RCH(NH2)ṁ(CH2)nṁC(OH)R2 have been studied The most striking action of these compounds is their ability to produce a sustained tremor, which is compared with those produced by other tremorogenic agents.
A, AHMED, P B, MARSHALL, D M, SHEPHERD
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Selective N‐Alkylation of Unprotected Amino Sugars by Alcohols. Application to the Synthesis of Sugar‐Based Surfactants

ChemistryEurope
A method for direct N‐functionalization of unprotected amino sugars using alcohols as alkylating agents is presented. The method relies on an iridium‐catalyzed hydrogen borrowing strategy, offering a direct and highly effective approach for modifying ...
Aitor Bermejo‐López, Beatriz Saavedra, Kevin M. Dorst, María Obieta, Patrick Maguire, Elisa Martínez‐Castro, Göran Widmalm, Belén Martín‐Matute   +7 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Harnessing nitroarenes as nitrogen and oxygen sources for general oxo-aminomethylation of alkenes

Nature Communications
Amino alcohols are essential synthetic building blocks and privileged motifs in drug development, playing a crucial role in modulating pharmacokinetics and biological activity.
Ting Zhou, Jing Nie, Chi Wai Cheung, Jun-An Ma   +3 more
doaj   +1 more source