Results 1 to 10 of about 805 (84)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Aminoacyltransferase Stimulation of Protein Synthesis by Pig Adrenal Polysomes [PDF]

Nature, 1967
ADMINISTRATION of adrenocorticotrophin in vivo increases the incorporation of 14C-glycine into protein by the supernatant of adrenal homogenates centrifuged at 15,000g1. A factor of the soluble cell fraction (105,000g supernatant) has been shown to be rate limiting for in vitro protein synthesis and its activity is doubled by ACTH administration in ...
Scriba, Peter Christian, Fries, M.
openaire   +3 more sources

A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S

Proceedings of the National Academy of Sciences, 2021
Significance Transfer RNA (tRNA) transfer appropriately activated amino acids to the end of the growing peptide chain, playing significant roles in primary metabolism. Importantly, tRNA have also been shown to function outside of translation.
Xiankun Wang, Yuchun Zhao, Yaojie Gao, Xiangkun Luo, Aiqin Du, Zixin Deng, T. Mark Zabriskie, Xinyi He, Ming Jiang   +8 more
openaire   +3 more sources

Bile salt hydrolase/aminoacyltransferase shapes the microbiome

, 2022
Abstract Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome due to their antimicrobial properties. Recently, a novel mechanism of BA metabolism by the gut microbiota was identified involving conjugation with various amino acids.
Douglas Guzior, Maxwell Okros, Christian Martin Hernandez, Madison Shivel, Bruin Armwald, Robert Hausinger, Robert Quinn   +6 more
openaire   +1 more source

An Aminoacyltransferase Preparation from Beef Liver

Journal of Biological Chemistry, 1966
Abstract An aminoacyltransferase preparation has been obtained from a beef liver homogenate, and a 44-fold purification of the activity has been achieved. The enzyme preparation catalyzes both peptide synthesis from suitable amino acid esters (e.g.
T A, Krenitsky, J S, Fruton
openaire   +2 more sources

Purification of Aminoacyltransferase II (Translocation Factor) from Rat Liver

Journal of Biological Chemistry, 1969
Abstract Aminoacyltransferase II is one of the two soluble protein factors required for polypeptide biosynthesis from aminoacyl transfer RNA with rat liver preparations. This transfer factor and guanosine triphosphate are required for the translocation of messenger RNA and peptidyl transfer RNA from the aminoacyl to the peptidyl site on ribosomes.
W, Galasinski, K, Moldave
openaire   +2 more sources

Aminoacyltransferase I-catalysed binding of phenylalanyl-transfer ribonucleic acid to muscle ribosomes from normal and diabetic rats [PDF]

Biochemical Journal, 1971
The aminoacyltransferase I-catalysed binding of phenylalanyl-tRNA (unfractionated Escherichia coli B tRNA acylated with radioactive phenylalanine and 19 non-radioactive amino acids) to skeletal-muscle ribosomes from diabetic rats was less than that to ribosomes from normal rats when the Mg2+ concentration was low (7.5mm); whereas just the reverse was ...
D P, Leader, I G, Wool, J J, Castles
openaire   +2 more sources

Evidence for the Role of Aminoacyltransferase II in Peptidyl Transfer Ribonucleic Acid Translocation

Journal of Biological Chemistry, 1968
Abstract When ribosomes are pretreated with transferase II and guanosine triphosphate, the binding of aminoacyl transfer ribonucleic acid to ribosomes in the presence of transferase I and the GTP analogue 5'-guanylyl methylenediphosphonate is markedly increased. Binding of aminoacyl-tRNA to ribosomes is also obtained in the absence of transferase I and
L, Skogerson, K, Moldave
openaire   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

British Journal of Pharmacology, Volume 176, Issue S1, Page S297-S396, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Annie Beuve, Detlev Boison, Peter Brouckaert, John C Burnett, Kathryn Burns, Carmen Dessauer, Andreas Friebe, John Garthwaite, Jürg Gertsch, Nuala Helsby, Angelo A Izzo, Doris Koesling, Michaela Kuhn, Rennolds Ostrom, Andreas Papapetropoulos, Lincoln R Potter, Nigel J Pyne, Susan Pyne, Michael Russwurm, Harald HHW Schmidt, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts   +39 more
wiley   +1 more source