Results 11 to 20 of about 840 (114)

Evolutionary Mechanisms of Long-Term Genome Diversification Associated With Niche Partitioning in Marine Picocyanobacteria. [PDF]

, 2020
Marine picocyanobacteria of the genera Prochlorococcus and Synechococcus are the most abundant photosynthetic organisms on Earth, an ecological success thought to be linked to the differential partitioning of distinct ecotypes into specific ecological ...
Aury J-M, Bisch A, Brillet-Guéguen L, Choi DH, Corre E, Doré H, Eveillard D, Farrant GK, Garczarek L, Guyet U, Haguait J, Hoebeke M, Humily F, Labadie K, Le Corguillé G, Noh JH, Ostrowski M, Partensky F, Pitt FD, Ratin M, Scanlan DJ, Six C, Wincker P   +22 more
core   +5 more sources

Unveiling the mechanism of action of 7α-acetoxy-6β-hydroxyroyleanone on an mrsa/visa strain: Membrane and cell wall interactions [PDF]

, 2020
UIDB/00100/2020 PTDC/MED-QUI/29036/2017 CEECIND/03414/2018 UIDB/04378/2020 PTDC/BIA-MIC/31645/2017 UID/DTP/04138/2019 UID/DTP/04567/2019 CBIOS/PRUID/BI1/2017 UIDB/04567/2020 UID/AMB/50017 UIDP/50017/2020 UIDB/50017/2020The number of cases of failure ...
Antunes, Catarina A. C., Ascensão, Lia, de Almeida, Rodrigo F. M., Figueiredo, Teresa A., Garcia, Catarina, Pereira, Filipe, Reis, Catarina P., Rijo, Patricia, Sobral, Rita G.   +8 more
core   +1 more source

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]

, 2006
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S., Davydov, Ilia V., Hu, Rong-Gui, Kwon, Yong Tae, Sheng, Jun, Varshavsky, Alexander, Wang, Haiqing, Zhou, Jianmin   +7 more
core   +2 more sources

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Structural and functional basis of mitochondrial tRNA processing [PDF]

, 2017
The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS).
Sridhara, Sagar
core   +1 more source

Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant [PDF]

Journal of the American Chemical Society, 2019
Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of its unusual structure, apramycin is not susceptible to the most prevalent mechanisms of aminoglycoside resistance ...
Jonathan C. K. Quirke, Parasuraman Rajasekaran, Vikram A. Sarpe, Amr Sonousi, Ivan Osinnii, Marina Gysin, Klara Haldimann, Qiao-Jun Fang, Dimitri Shcherbakov, Sven N. Hobbie, Su-Hua Sha, Jochen Schacht, Andrea Vasella, Erik C. Böttger, David Crich   +14 more
openaire   +3 more sources

TOR‐mediated regulation of metabolism in aging

Aging Cell, Volume 16, Issue 6, Page 1219-1233, December 2017., 2017
Summary Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms.
Henri Antikainen, Monica Driscoll, Gal Haspel, Radek Dobrowolski   +3 more
wiley   +1 more source

Ribosome‐independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

FEBS Letters, Volume 586, Issue 15, Page 2065-2075, July 16, 2012., 2012
Peptide natural products continue to play an important role in modern medicine as last‐resort treatments of many life‐threatening diseases, as they display many interesting biological activities ranging from antibiotic to antineoplastic. A large fraction of these microbial natural products is assembled by ribosome‐independent mechanisms.
Tobias W. Giessen, Mohamed A. Marahiel
wiley   +1 more source

Design principles of cell-free replicators [PDF]

, 2021
Der heilige Gral der synthetischen Biologie ist die Erschaffung einer minimalen Zelle, welche sowohl zu autonomer Selbstreplikation als auch zu natürlicher Evolution befähigt ist.
Libicher, Kai
core  

Study of a Bacillus circulans chitin-binding domain by a green fluorescent protein binding assay and detection of lysozymes by improved zymograms [PDF]

, 2002
A fluorescent binding assay was developed to investigate the effects of site-directed mutagenesis on the binding affinity and binding specificity of the chitin-binding domain of chitinase A1 from Bacillus circulans WL-12. The chitin-binding domain (ChBD)
Hardt, Markus
core   +2 more sources