Results 21 to 30 of about 1,287 (121)

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

1H‐Nuclear Magnetic Resonance Metabolic Profiling of Pantaneiro and Curraleiro Beef Breeds: Unveiling Adaptation Mechanisms in Brazilian Livestock

New Zealand Journal of Agricultural Research, Volume 69, Issue 1, February 2026.
This study provides the first metabolomic characterization of serum from Pantaneiro and Curraleiro beef cattle, unveiling their unique adaptations to the Pantanal and Cerrado biomes of Brazil. Blood was collected during the summer season to capture metabolic responses to extreme environmental conditions, including high temperatures and varying humidity.
Eduardo Solano Pina dos Santos, Vinicius Laerte Silva Herreira, Ana Laura dos Santos Munhoz Gôngora, Gabriel Henrique Ribeiro, Luiz Alberto Colnago, Brenda Santos de Oliveira, Fernanda Maria Marins Ocampos, Alanne Tenório Nunes, Yasmin Gonçalves da Silva de Souza, Rafael Henrique de Tonissi e Buschinelli de Góes, Yash Dixit, Marlon Martins Reis, Nara Regina Brandão Cônsolo   +12 more
wiley   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source

Whey as an Environmental Issue and Its Possible Solutions: Its Utilization as Culture Medium to Produce L‐Threonine Through E. coli in a Bioreactor

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Whey, a by‐product of the cheese manufacturing industry, represents one of the most abundant and polluting effluents in the global food industry. Despite traditionally being underutilized and often discarded, its rich nutrient profile, particularly protein and lactose, has increasingly sparked an interest in its value within biotechnological processes.
Sara Pineda Vélez, Yudy Natalia Cortés Velásquez, Claudia Patricia Sánchez Henao, Jhon Fredy Vélez Blandón, Rabindranath Paul   +4 more
wiley   +1 more source

The Analgesic Enhancing Effects of Coupling M1 and PMC rTMS on Neuropathic Pain After Spinal Cord Injury: An fNIRS Study

Pain Research and Management, Volume 2026, Issue 1, 2026.
Background Repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) shows promise for treating neuropathic pain (NP) after spinal cord injury (SCI), but its efficacy remains limited. This study investigated whether combining rTMS on M1 with premotor cortex (PMC) could improve pain relief in SCI patients with NP ...
Xiangbo Wu, Mulan Xu, Wei Sun, Xiaodong Lin, Baijie Xue, Fen Ju, Tao Han, Xinyu Liu, Chenguang Zhao, Xiaolong Sun, Hua Yuan, Filippo Brighina   +11 more
wiley   +1 more source

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

Chemistry–Methods, Volume 5, Issue 12, November 2025.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy, Jannik Sprengel, Claire Cannet, Nils Pompe, Christoph Trautwein   +4 more
wiley   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Structure, biogenese et roles fonctionnels des poly alpha-aminobutyrates elabores sous controle bacterien dans les nodosites de Medicago sativa L

, 1985
SIGLECNRS T 57979 / INIST-CNRS - Institut de l'Information Scientifique et ...
Gerant Sauvage, D.
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The Diuretic Effect of Sacubitril/Valsartan Might Be Clinically Relevant

Arquivos Brasileiros de Cardiologia
Luís Beck-da-Silva, Luís E. Rohde
doaj   +1 more source