Results 11 to 20 of about 1,287 (121)

Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐Bis‐Carbofunctionalization

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee, Che‐Ming Hsu, Shinje Miñoza, Ya‐Fang Shih, Yu‐Chun Ding, Tzu‐Yao Hsu, Song‐Ting Chen, Kuei‐Chen Chang, Wen‐Hsuan Lee, Yuya A. Lin, Hsuan‐Hung Liao   +10 more
wiley   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Dehydration‐driven organization of metabolites into NaDES‐like assemblies in orthodox seeds

New Phytologist, EarlyView.
Summary Desiccation tolerance in plants, especially during orthodox seed dehydration, relies on compatible solute accumulation, complex molecular mechanisms, and intermolecular organizations that remain poorly understood. We combined metabolite profiling, mass spectrometry imaging, and electrospray and cold‐spray ionization mass spectrometry to ...
Youcef Haddad, Thomas Delhaye, Emmanuelle Limanton, Denis Morineau, Maëna Le Corvec, Christine Deponge, Anne Levrel, Alain Moréac, Virginie Nazabal, David Rondeau, Ludovic Paquin, Alain Bouchereau   +11 more
wiley   +1 more source

Intrapopulation Metabolic Variation Reflects Growth Differences: A Cross‐Sectional Study on Gammarides

Ecology and Evolution, Volume 16, Issue 5, May 2026.
For the first time in Gammarus insensibilis, a single‐organism 1H NMR metabolomics approach was applied to investigate the intrapopulation variability in growth trajectories showing how divergent size classes, despite being of the same age, reflect alternative resource‐allocation strategies.
Federica De Castro, Ludovico Lezzi, Milad Shokri, Laura Del Coco, Francesco Paolo Fanizzi, Alberto Basset   +5 more
wiley   +1 more source

Blood‐Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 5, May 2026.
This study represents the first epigenome‐wide association analysis of Alcohol Use Disorder (AUD) in a genetically and culturally diverse Brazilian cohort. Genome‐wide DNA methylation profiling revealed hypomethylation in genes and pathways related to neuronal development, synaptic organization, intracellular signaling and cellular stress responses in ...
Laís da Silva Pereira‐Rufino, Raissa Mazzer de Sino Romano, Regiane Chiavelli Lamim, Rafael Conte, Denise Ribeiro Gobbo, Marcelo Carvalho da Conceição, Vanessa Kiyomi Ota, Lucas Liro, Leslie Domenici Kulikowsk, Adriana Marcassa Tucci, Ana Lucia de Moraes Horta, Ana Maria Sebastião, Maria Lucia Oliveira Souza‐Formigoni, João Ricardo Nickenig Vissoci, Alexandre Ferro Aissa, Isabel Cristina Céspedes   +15 more
wiley   +1 more source

Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao, Yeke Ni, Yu Wang, John M. Ward, Jack W. E. Jeffries, Helen C. Hailes   +5 more
wiley   +1 more source

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, Volume 3, Issue 1, March 2026.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Differences in Phenylpropanoid and Reactive Oxygen Species Genes Drive Plastic and Adaptive Responses to Drought Stress Between Douglas‐Fir Varieties and Hybrids

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Warming climates bring significant challenges to the survival and growth of conifer species, yet the genomic basis of drought resistance is poorly understood. In this study, we used a common garden experiment to combine genomic, physiological and transcriptomic analysis to dissect plastic and adaptive responses to drought between Douglas‐fir ...
Kailey Baesen, Amanda Fitzhugh, Amanda R. De La Torre   +2 more
wiley   +1 more source

Priming Salt Resilience in Melon (Cucumis melo) via Pseudomonas oryzihabitans‐Mediated Metabolic Reprogramming

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Melon (Cucumis melo L.) is a globally significant crop, yet its productivity is increasingly threatened by rising soil salinity in many cultivation areas. In this context, plant growth‐promoting rhizobacteria (PGPR) have emerged as a promising strategy to enhance plant growth and improve tolerance to salinity stress.
Anastasia Papadopoulou, Ifigeneia Gkourmi, Theodora Matsi, Aliki Xanthopoulou, Kalliopi Kadoglidou, Aikaterini Triantafyllou, Katerina Karamanoli, Ifigeneia Mellidou   +7 more
wiley   +1 more source