Results 11 to 20 of about 3,917 (163)

2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We examined the impact of mid‐life metabolites on late‐life Alzheimer's disease (AD) plasma biomarkers and whether these metabolites mediate air pollution effects. METHODS In the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) cohort, we applied high‐dimensional regression and mediation models, adjusting for ...
Saeed A, Mckennan C, Clougherty JE, Zhou P, Tripathy S, Kinnee EJ, Duan J, Kip K, Zeng X, Villemagne V, Pascoal T, Mapstone M, Whitsel EA, Lopez OI, Ballantyne C, Karikari TK, Yu B, Reis S, Cohen A.   +18 more
europepmc   +2 more sources

γ-Aminobutyrate Improves the Postharvest Marketability of Horticultural Commodities: Advances and Prospects

Frontiers in Plant Science, 2022
Postharvest deterioration can result in qualitative and quantitative changes in the marketability of horticultural commodities, as well as considerable economic loss to the industry.
Morteza Soleimani Aghdam, Edward J. Flaherty, B. Shelp   +2 more
semanticscholar   +1 more source

Exogenous GABA enhances muskmelon tolerance to salinity-alkalinity stress by regulating redox balance and chlorophyll biosynthesis

BMC Plant Biology, 2019
BackgroundSalinity-alkalinity stress is one of the major abiotic stresses affecting plant growth and development. γ-Aminobutyrate (GABA) is a non-protein amino acid that functions in stress tolerance.
Xiaoqing Jin, Tao Liu, Jiaojiao Xu, Zixing Gao, Xiaohui Hu   +4 more
semanticscholar   +1 more source

Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice

Journal of Immunological Research, 2020
Colorectal cancer (CRC) is the fourth leading cause of tumor‐related deaths worldwide. In this study, we explored the in vivo effects of quercetin, a plant flavonol from the flavonoid group of polyphenols with antioxidant effects, on colon carcinogenesis
R. Lin, Meiyu Piao, Yan Song, Chunyan Liu   +3 more
semanticscholar   +1 more source

Differential Metabolomics Reveals Ophthalmic Acid as an Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption*

Journal of Biological Chemistry, 2006
Metabolomics is an emerging tool that can be used to gain insights into cellular and physiological responses. Here we present a metabolome differential display method based on capillary electrophoresis time-of-flight mass spectrometry to profile liver ...
T. Soga, R. Baran, M. Suematsu, Y. Ueno, Satsuki Ikeda, Tadayuki Sakurakawa, Yuji Kakazu, Takamasa Ishikawa, M. Robert, T. Nishioka, M. Tomita   +10 more
semanticscholar   +1 more source

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain

Biomolecules, 2016
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur James Cooper, T. Jeitner
semanticscholar   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +2 more sources

GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer

Journal of experimental & clinical cancer research : CR
Brain metastasis (BrM) poses a significant challenge to the prognosis and quality of life for patients with non-small cell lung cancer (NSCLC). Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system (CNS), has been ...
Mengqing Xie, H. Qin, Li Liu, Jing Wu, Zhikai Zhao, Yaodong Zhao, Yujia Fang, Xin Yu, Chunxia Su   +8 more
semanticscholar   +1 more source

Comparative In silico Analysis of Butyrate Production Pathways in Gut Commensals and Pathogens

Frontiers in Microbiology, 2016
Biosynthesis of butyrate by commensal bacteria plays a crucial role in maintenance of human gut health while dysbiosis in gut microbiome has been linked to several enteric disorders.
S. Anand, Harrisham Kaur, S. S. Mande
semanticscholar   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source