Results 41 to 50 of about 6,621 (153)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

COMPARATIVE EVALUATION OF THE EFFICACY OF AMINOCAPROIC AND TRANEXAMIC ACIDS DURING HEART SURGERY

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
Objectives. To perform a comparative analysis of the efficacy of aminocaproic (EACA) and tranexamic acid (TX) for heart surgery with cardiopulmonary bypass (CPB). Material and methods.
Osipenko D. V., Salivonchik S. P., Skarakhodau A. A., Silanau A. A., Marochkov A. V.   +4 more
doaj   +1 more source

Comparative metabolic profiling of wild Cordyceps species and their substituents by liquid chromatography-tandem mass spectrometry

Frontiers in Pharmacology, 2022
Cordyceps is a genus of ascomycete fungi and used widely in fungal drugs. However, in-depth studies of the metabolites of wild Cordyceps species and their substituents are lacking. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Shan Guo, Manting Lin, Manting Lin, Di Xie, Wenqing Zhang, Mi Zhang, Li Zhou, Sheng Li, Sheng Li, Sheng Li, Hankun Hu, Hankun Hu   +11 more
doaj   +1 more source

Antisense reduction in NADP‐ME in the C4 species Flaveria bidentis alters stomatal sensitivity to intercellular [CO2]

New Phytologist, EarlyView.
Summary Stomata have the crucial role of balancing the uptake of CO2 for photosynthesis and water loss via transpiration by adjusting their aperture. In C3 plants, coordination between photosynthesis and stomatal conductance can be disrupted by mutations in Calvin–Benson–Bassham (CBB) cycle expression, but it is not clear whether the disruption of the ...
Emmanuel L. Bernardo, Cristina Rodrigues Gabriel Sales, Tianshu Sun, Johannes Kromdijk   +3 more
wiley   +1 more source

Platelet Levels Associated With Bleeding Risk for Dental Interventions: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objectives To evaluate evidence in relation to postoperative bleeding in humans aged ≥ 16 with preoperative platelet counts < 50,000/μL, compared to those above, undergoing dental interventions. Methods Quantitative synthesis without meta‐analysis was conducted through an electronic search conducted on Ovid MEDLINE and Embase from 1946 to ...
Guang Xu David Lim, Fatima Al Sarraf, Hana Cho, Navdeep Kumar   +3 more
wiley   +1 more source

Intraorgan use of Hemoblock for prevention and arrest of bleedings in endoscopic excision of gastric polyps

Неотложная медицинская помощь, 2019
INTRODUCTION Bleedings after endoscopic removal of gastric polyps continue to be a relevant issue. A technique has been developed for infltrating the base of polyps with a new hemostatic agent Hemoblock to prevent bleedings during polypectomy.
S. G. Tereshchenko, A. V. Plotkin, L. V. Mecheva   +2 more
doaj   +1 more source

Microwave Assisted Selective Hydrolysis of Polyamides from Multicomponent Carpet Waste

Global Challenges, 2021
Selective hydrolysis of polyamide‐6 (PA‐6) and polyamide‐66 (PA‐66) from commercial multicomponent PA‐6/PA‐66/polypropylene (PP) carpet is demonstrated by a microwave‐assisted acid catalyzed hydrothermal process, yielding monomeric products and solid ...
Eva Bäckström, Karin Odelius, Minna Hakkarainen   +2 more
doaj   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Biohybrid Tendons Enhance the Power‐to‐Weight Ratio and Modularity of Muscle‐Powered Robots

Advanced Science, Volume 13, Issue 15, 13 March 2026.
Biohybrid robots powered by skeletal muscle actuators are capable of dynamically adapting to environmental cues. This study takes inspiration from native muscle–tendon architecture by leveraging tough hydrogels as synthetic tendons for muscle actuators to enhance the power‐to‐weight ratio and modularity of biohybrid machines.
Nicolas Castro, Ronald Heisser, Maheera Bawa, Bastien Aymon, Sarah Wu, Annika Marschner, Sonika Kohli, Angel Bu, Laura Rosado, Martin Culpepper, Xuanhe Zhao, Ritu Raman   +11 more
wiley   +1 more source

Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed, Abdallah Alhalabi, Didier Gasparutto, Xavier Le Guével   +3 more
wiley   +1 more source