Results 151 to 160 of about 69,960 (284)

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song   +10 more
wiley   +1 more source

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3017-3026, September 2026.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood   +6 more
wiley   +1 more source

Biofilm-Forming Capacity and <i>fimH</i> Gene Prevalence Among Uropathogenic <i>Klebsiella</i> spp. in Gabon: Assessing the Link with Resistance to Third-Generation Cephalosporins and Aminoglycosides. [PDF]

open access: yesAntibiotics (Basel)
Mayombo Ngoussou E   +9 more
europepmc   +1 more source

Ramelteon and Mortality in Patients With Sepsis and Cancer: Insights From a Propensity‐Matched Analysis of the MIMIC‐IV Database

open access: yesCancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Purpose This study aimed to evaluate the association between ramelteon use and mortality outcomes in patients with sepsis and cancer. The research question was whether ramelteon use is associated with reduced mortality in this high‐risk patient population. Methods A retrospective analysis of the MIMIC‐IV database was conducted.
Chendong Wang, Mingjie Liu, Jia Song
wiley   +1 more source

Acinetobacter baumannii resistance trends in an ICU from Saudi Arabia over 12 years. [PDF]

open access: yesIndian J Med Res
Shabi Y   +13 more
europepmc   +1 more source

Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug‐Resistant Bacteria: Preliminary Antibiotic–Interaction Screening and Exploratory Molecular Docking

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri   +11 more
wiley   +1 more source

In Silico and In Vitro Evaluation of Atriplex halimus: Antibacterial Activity, Molecular Docking, ADMET Profiling, and Cytotoxicity Assessment

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Atriplex halimus aqueous and hydroethanolic extracts, rich in trans‐cinnamic acid, catechin, epigallocatechin, and vitamin C. The Extracts showed modest antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and dose‐dependent cytotoxicity in Artemia salina.
Mohammed Roubi   +10 more
wiley   +1 more source

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